PZ0374

PF-06446846 hydrochloride

≥98% (HPLC)

• Synonym(s): N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₀ClN₇O · xHCl
• CAS Number: 1632250-50-0
• Molecular Weight: 433.89 (free base basis)
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -60 to -50°, c = 1 in methanol
• manufacturer/tradename: Pfizer^®
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• originator: Pfizer
• storage temp.: room temp
• SMILES string: O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5

Description

Packaging

5, 25 mg

Biochem/physiol Actions

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3