QC testing of the product utilizes the solvents Pyridine and Methanol. Rutin is reported to be soluble in DMSO at approximately 25 mg/ml. Solvents should be purged with an inert gas before use. No data is available concerning the product's cell toxicity.
R5143
Rutin hydrate
≥94% (HPLC), powder
Synonym(s):
Quercetin-3-rutinoside hydrate, Vitamin P hydrate
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| Size/SKU | Availability | Price |
|---|---|---|
50 g | Available to ship TODAYfromSigma-Aldrich Gillingham | £83.40 |
100 g | Available to ship TODAYfromSigma-Aldrich Gillingham | £144.00 |
500 g | Available to ship TODAYfromSchnelldorf Distribution | £508.00 |
About This Item
Empirical Formula (Hill Notation):
C27H30O16 · xH2O
CAS Number:
Molecular Weight:
610.52 (anhydrous basis)
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
205-814-1
Beilstein/REAXYS Number:
75455
MDL number:
Quality Segment
assay
≥94% (HPLC)
form
powder
color
yellow to green
mp
195 °C (dec.) (lit.)
solubility
pyridine: 50 mg/mL, DMSO: soluble, aqueous base: soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
SMILES string
[H]O[H].O[C@H]1[C@H](OC[C@H]([C@H]2O)O[C@@H](OC(C3=O)=C(C4=CC=C(O)C(O)=C4)OC5=C3C(O)=CC(O)=C5)[C@H](O)[C@H]2O)O[C@H]([C@@H]([C@H]1O)O)C
InChI
1S/C27H30O16.H2O/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9;/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3;1H2/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-;/m0./s1
InChI key
PGHSKTKIQIBATG-ZAAWVBGYSA-N
General description
Rutin hydrate has radioprotective and antiplatelet activity. Rutin reduces hepatic and blood cholesterol levels.
Application
Rutin hydrate has been used:
- as an inhibitory compound against Skeletonema costatum[1]
- to analyze the phenolic component and antioxidant activity of nettle
- to assess the flavonoid content in Propolis
Biochem/physiol Actions
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.
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This Item | |||
|---|---|---|---|
| assay ≥94% (HPLC) | assay ≥94.0% (HPLC) | assay ≥95.0% (HPLC) | assay - |
| form powder | form - | form - | form - |
| application(s) metabolomics | application(s) food and beverages | application(s) food and beverages | application(s) - |
| solubility pyridine: 50 mg/mL, aqueous base: soluble, DMSO: soluble | solubility - | solubility - | solubility - |
| color yellow to green | color - | color - | color - |
| mp 195 °C (dec.) (lit.) | mp - | mp - | mp - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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In what amount of DMSO does rutin completely dissolve and is it not toxic to cells?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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