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SML0341

Sigma-Aldrich

Importazole

≥98% (HPLC)

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Synonym(s):
N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
Empirical Formula (Hill Notation):
C20H22N4
CAS Number:
Molecular Weight:
318.42
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4

InChI

1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

InChI key

HKGJEZIGDHFJFL-UHFFFAOYSA-N

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SML2850401105SML1037
Importazole ≥98% (HPLC)

Sigma-Aldrich

SML0341

Importazole

Cediranib ≥98% (HPLC)

Sigma-Aldrich

SML2850

Cediranib

Importazole A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.

Sigma-Aldrich

401105

Importazole

UNC0642 ≥98% (HPLC)

Sigma-Aldrich

SML1037

UNC0642

form

powder

form

powder

form

solid

form

powder

color

white to beige

color

white to beige

color

white

color

white to beige

solubility

DMSO: >5 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 25 mg/mL, clear, colorless

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

Application

Importazole has been used:
  • to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
  • to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
  • as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
  • as a functional inhibitor of Importin β in embryo treatment
  • as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS

Biochem/physiol Actions

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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