SML1061

PF-04856264

≥98% (HPLC)

• Synonym(s): 3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide
• Empirical Formula (Hill Notation): C₂₀H₁₅N₅O₃S₂
• CAS Number: 1235397-05-3
• Molecular Weight: 437.49
• NACRES: NA.77
• PubChem Substance ID: 329825643
• UNSPSC Code: 12352200
• MDL number: MFCD28124397

Properties

• InChI key: MKSKJVIBSRUWSZ-UHFFFAOYSA-N
• SMILES string: O=S(C(C=C1)=CC(C#N)=C1OC2=CC=CC=C2C3=CC=NN3C)(NC4=NC=CS4)=O
• InChI: 1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Description

Biochem/physiol Actions

PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC₅₀ = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC₅₀ = 131 nM) but has low potency against the rat Nav1.7 channel (IC₅₀ = 4.2 mM).

PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable