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SML1643

Sigma-Aldrich

AS2444697

≥98% (HPLC)

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Synonym(s):
AS 2444697, N-[3-(Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl-2-(2-methyl-4-pyridinyl)-4-Oxazolecarboxamide hydrochloride (1:1), N-[3-Carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide
Empirical Formula (Hill Notation):
C19H20N6O4 · HCl
CAS Number:
Molecular Weight:
432.86
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=CN(C4CCOCC4)N=C3C(N)=O.[H]Cl

InChI

1S/C19H20N6O4.ClH/c1-11-8-12(2-5-21-11)19-23-15(10-29-19)18(27)22-14-9-25(24-16(14)17(20)26)13-3-6-28-7-4-13;/h2,5,8-10,13H,3-4,6-7H2,1H3,(H2,20,26)(H,22,27);1H

InChI key

FGNHLIIFEDYNFZ-UHFFFAOYSA-N

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AS2444697 ≥98% (HPLC)

Sigma-Aldrich

SML1643

AS2444697

BAZ2-ICR ≥98% (HPLC)

Sigma-Aldrich

SML1276

BAZ2-ICR

GSK343 ≥98% (HPLC)

Sigma-Aldrich

SML0766

GSK343

PF-4191834 ≥98% (HPLC)

Sigma-Aldrich

PZ0360

PF-4191834

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

, white to beige to brown

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Application

AS2444697 has been used as an interleukin-1R-associated kinase 4 (IRAK4) inhibitor to study the role of interleukin (IL)-1/IL-33 signaling in the development of endometriosis using a mouse model of endometriosis. It has also been used to study its dose-dependent effect on the C-X-C motif chemokine ligand 8 (CXCL8) gene expression

Biochem/physiol Actions

AS2444697 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4) that suppresses the progression of chronic renal failure via anti-inflammatory action.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis.
Keith A Sikora et al.
The Journal of allergy and clinical immunology, 141(5), 1943-1947 (2018-02-11)
Toru Kato et al.
Frontiers in immunology, 10, 2021-2021 (2019-09-12)
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither

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