SML1674

UPCDC30245

≥98% (HPLC)

• Synonym(s): 1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine
• Empirical Formula (Hill Notation): C₂₈H₃₈FN₅
• CAS Number: 1883351-01-6
• Molecular Weight: 463.63
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826009
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Properties

• InChI key: LZHXZCVDLATFAR-UHFFFAOYSA-N
• SMILES string: FC1=CC=C(NC(C2=CC=CC(N3CCC(NCCN4CCN(C(C)C)CC4)CC3)=C2)=C5)C5=C1
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Description

Biochem/physiol Actions

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). p97 is an integral component of the ubiquitin fusion degradation (UFD) pathway. It plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. UPCDC30245 has an IC₅₀ value of 27 nM, and has been shown to bind at the junction between the D1 and D2 domains of p97. UPCDC30245 has been used in cryo-ECM to show how such inhibitor binding prevents the confomational changes necessary for p97 function.

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable