Merck
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SML2032

Sigma-Aldrich

Win6mer trifluoroacetate salt

≥98% (HPLC)

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Synonym(s):
Ac-ARTEVY-NH2 trifluouroaceate salt
Empirical Formula (Hill Notation):
C34H54N10O11 · xC2HF3O2
Molecular Weight:
778.85 (free base basis)
NACRES:
NA.77

Assay

≥98% (HPLC)

form

film (Clear)

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

SMILES string

C[C@H](NC(C)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O

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This Item
A5855SML1132R3905
form

film (Clear)

form

film

form

solution

form

lyophilized solid

color

white to off-white

color

yellow

color

colorless to pale yellow

color

white

shipped in

wet ice

shipped in

-

shipped in

wet ice

shipped in

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

Biochem/physiol Actions

Win6mer is a potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes that does not inhibit MLL2-4 or SETd1B complexes. Win6mer potently binds to WDR5 in a 310-helical conformation. It does not inhibit isolated SET domain activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Nilda L Alicea-Velázquez et al.
The Journal of biological chemistry, 291(43), 22357-22372 (2016-08-27)
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family members are associated with cancer and developmental disorders. MLL1 associates

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