SML2234

1S,3R-RSL 3

≥98% (HPLC)

• Synonym(s): (1S, 3R)-2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
• Empirical Formula (Hill Notation): C₂₃H₂₁ClN₂O₅
• CAS Number: 1219810-16-8
• Molecular Weight: 440.88
• MDL number: MFCD30187526
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C

Description

Application

1S,3R-RSL 3 has been used:

• as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) lines
• GPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in mice
• as a ferroptosis inducer in HT-1080 cellsin cell viability assay

Biochem/physiol Actions

RSL3 is an inducer of ferroptosis. It acts by a different method than erastin to induce ferroptosis by inhibiting glutathione peroxidase 4 (GPX4).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable