SML2760

SGC6870

≥98% (HPLC)

• Synonym(s): (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
• Empirical Formula (Hill Notation): C₂₃H₂₁BrN₂O₂S
• Molecular Weight: 469.39

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +260 to +300°, c = 0.5 in methanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Description

Packaging

5, 25 mg

Biochem/physiol Actions

SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC₅₀ = 77 nM by cell-free assays; IC₅₀ = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3