Merck
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SML3011

Sigma-Aldrich

MG149

≥98% (HPLC)

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Synonym(s):
2-(4-Heptylphenethyl)-6-hydroxybenzoic acid, 2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid, MG 149
Empirical Formula (Hill Notation):
C22H28O3
CAS Number:
Molecular Weight:
340.46
MDL number:

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O

InChI

1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)

InChI key

WBHQYBZRTAEHRR-UHFFFAOYSA-N

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This Item
S7401A7960484210
MG149 ≥98% (HPLC)

Sigma-Aldrich

SML3011

MG149

Salicylic acid suitable for plant cell culture

Sigma-Aldrich

S7401

Salicylic acid

4-Aminosalicylic acid 99%

Sigma-Aldrich

A79604

4-Aminosalicylic acid

Salicylic acid puriss. p.a., ≥99.0% (T)

Sigma-Aldrich

84210

Salicylic acid

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

-

color

white to beige

color

-

solubility

DMSO: 2 mg/mL, clear

solubility

ethanol: 50 mg/mL

solubility

-

solubility

96% ethanol: 0.1 g/mL, clear

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

Biochem/physiol Actions

MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Liming Yu et al.
Circulation, 138(24), 2820-2836 (2018-07-19)
Excessive accumulation of reactive oxygen species (ROS), catalyzed by the NADPH oxidases (NOX), is involved in the pathogenesis of ischemia-reperfusion (IR) injury. The underlying epigenetic mechanism remains elusive. We evaluated the potential role of megakaryocytic leukemia 1 (MKL1), as a
Thea van den Bosch et al.
Pulmonary pharmacology & therapeutics, 44, 88-95 (2017-03-23)
Lysine acetylations are post-translational modifications of cellular proteins, that are crucial in the regulation of many cellular processes. Lysine acetylations on histone proteins are part of the epigenetic code regulating gene expression and are installed by histone acetyltransferases. Observations that
Massimo Ghizzoni et al.
European journal of medicinal chemistry, 47(1), 337-344 (2011-11-22)
Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elucidation of the biological functions of HATs

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