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SML3018

Sigma-Aldrich

TH1834

≥98% (HPLC)

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Synonym(s):
2-(5-(4-((Phenethyl(4-(4-(pyrrolidin-1-ylmethyl)phenoxy)butyl)amino)methyl)phenyl)-2H-tetrazol-2-yl)acetic acid dihydrochloride, 2H-Tetrazole-2-acetic acid, 5-[4-[[(2-phenylethyl)[4-[4-(1-pyrrolidinylmethyl)phenoxy]butyl]amino]methyl]phenyl]-, hydrochloride (1:2), TIP60i
Empirical Formula (Hill Notation):
C33H40N6O3 · 2HCl
CAS Number:
Molecular Weight:
641.63
MDL number:

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(O)CN1N=C(C2=CC=C(CN(CCC3=CC=CC=C3)CCCCOC4=CC=C(CN5CCCC5)C=C4)C=C2)N=N1.[H]Cl.[H]Cl

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This Item
SML3338SML1507SML1491
TH1834 ≥98% (HPLC)

Sigma-Aldrich

SML3018

TH1834

Sigma-Aldrich

Sigma-Aldrich

SML3338

NF-56-EJ40

GW501516 ≥98% (HPLC)

Sigma-Aldrich

SML1491

GW501516

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to beige

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Biochem/physiol Actions

TH1834 is a cell penetrant, potent and selective histone acetyltransferase (HAT) Tip60 inhibitor that interact with active binding pocket of Tip60. TH1834 induces apoptosis and increased unrepaired DNA damage in breast and prostate cancer cell lines but not control MCF10A cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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James A L Brown et al.
Biochemical Society transactions, 44(4), 979-986 (2016-08-17)
Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Importantly
Mouhamed Idrissou et al.
Omics : a journal of integrative biology, 24(10), 581-591 (2020-09-23)
Breast cancer is often sporadic due to several factors. Among them, the deregulation of epigenetic proteins may be involved. TIP60 or KAT5 is an acetyltransferase that regulates gene transcription through the chromatin structure. This pleiotropic protein acts in several cellular
Chunxia Gao et al.
Scientific reports, 4, 5372-5372 (2014-06-21)
Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general HAT inhibitors

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