Merck
All Photos(2)

SRP0461

Sigma-Aldrich

BRD4 (49-170) His tag human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

All Photos(2)
Synonym(s):
CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

15.5 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_058243

UniProt accession no.

O60885

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRD4(23476)

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BRD3 (29-145) His tag human recombinant, expressed in E. coli, ≥88% (SDS-PAGE)

Sigma-Aldrich

SRP0455

BRD3 (29-145) His tag human

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥88% (SDS-PAGE)

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

15.5 kDa

mol wt

14.9 kDa

mol wt

47.5 kDa

mol wt

14.9 kDa

packaging

pkg of 100 μg

packaging

pkg of 100 μg

packaging

pkg of 100 μg

packaging

pkg of 100 μg

General description

BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-170 with N-terminal His-tag, MW = 15.5kDa, expressed in an Escherichia coli expression system.

Biochem/physiol Actions

BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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