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Merck

T2320

T0901317

≥98%

Synonym(s):

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C17H12NSO3F9
CAS Number:
293754-55-9
Molecular Weight:
481.33
NACRES:
NA.25
PubChem Substance ID:
24900032
UNSPSC Code:
12352106
MDL number:
MFCD03412028

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InChI

1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

SMILES string

OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F

InChI key

SGIWFELWJPNFDH-UHFFFAOYSA-N

assay

≥98%

mol wt

481.3

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ABCA1(19), NR1H2(7376), NR1H3(10062)

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This Item
575310752924411140
T0901317 ≥98%

Sigma-Aldrich

T2320

T0901317

T0901317 A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα).

Sigma-Aldrich

575310

T0901317

2,2,2-Trifluoroethyl trifluoromethanesulfonate 95%

Sigma-Aldrich

752924

2,2,2-Trifluoroethyl trifluoromethanesulfonate

(S)-(+)-α-(Trifluoromethyl)benzyl alcohol 99%

Sigma-Aldrich

411140

(S)-(+)-α-(Trifluoromethyl)benzyl alcohol

assay

≥98%

assay

≥98% (HPLC)

assay

95%

assay

99%

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

mol wt

481.3

mol wt

-

mol wt

-

mol wt

-

Gene Information

human ... ABCA1(19), NR1H2(7376), NR1H3(10062)

Gene Information

-

Gene Information

-

Gene Information

-

Application

T0901317 has been used in LXR agonist study[1] in order to observe the expression of all dietary cholesterol-regulated genes in mice.[2] It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.[3]

Biochem/physiol Actions

LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression
T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.[4]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000446240
0000446240
0000443969
0000443969
0000316866

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Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins ACTIVATION OF StarD4 BY STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 AND StarD5 BY ENDOPLASMIC RETICULUM STRESS
Soccio RE, et al.
The Journal of Biological Chemistry, 280(19), 19410-19418 (2005)
The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
Maczewsky J, et al.
Endocrinology, 158(7), 2145-2154 (2017)
Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
Jahangir Iqbal et al.
Journal of lipid research, 59(11), 2084-2097 (2018-10-04)
Sphingolipids, including ceramide, SM, and hexosylceramide (HxCer), are carried in the plasma by lipoproteins. They are possible markers of metabolic diseases, but little is known about their control. We previously showed that microsomal triglyceride transfer protein (MTP) is critical to
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Maxwell KN, et al.
Journal of Lipid Research, 44(11), 2109-2119 (2003)
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