WH0010225M1

Monoclonal Anti-CD96 antibody produced in mouse

clone 3H8, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-CD96 antigen, Anti-DKFZp667E2122, Anti-MGC22596, Anti-TACTILE
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 3H8, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: suitable; western blot: 1-5 μg/mL
• isotype: IgG2aκ
• GenBank® accession no.: BC020749
• UniProt accession no.: P40200
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... CD96(10225)

Description

General description

CD96 (cluster of differentiation 96) belongs to the IgG (immunoglobulin) superfamily receptors. It is expressed in the spinal cord, kidney, trachea, digestive tissues, prostate, placenta, bone of adults and fetal brain and liver. This gene is located on human chromosome 3q13.

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. (provided by RefSeq)

Immunogen

CD96 (AAH20749, 1 a.a. ~ 402 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MEKKWKYCAVYYIIQIHFVKGVWEKTVNTEENVYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSRWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSGKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPASKNVFTLSY

Biochem/physiol Actions

CD96 (cluster of differentiation 96) plays major inhibitory roles in immune function. It helps to increase the cytotoxicity of natural killer (NK) cells. Mutations in CD9 result in C (Opitz Trigonocephaly) Syndrome.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

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Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves