MultiScreen® plates with 96- and 384-well capacities are available in many configurations and a diverse set of housing materials to assure compatibility with varied media formulations and solvents. Solid bottom plates are available for chemiluminescent and fluorescent screening assays, sample preparation and storage, and ELISA including 8-well strip format. Filter plates are invaluable for sample preparation including cell separation for flow cytometry, ELISpot, cell migration, invasion and chemotaxis, enzyme and receptor ligand binding, solubility and permeability assays, including PAMPA. Plates are automation compatible and designed for use with DirectStackTM vacuum workflow to minimize sample cross-talk. Product customization is available including barcodes, membrane selection, and packaging.
MultiScreen® filter plates were designed to work productively with sensitive detection and imaging systems, providing dependable and robust sample handling and precision transfer. Plates with 96- and 384-well capacity are fabricated using a diverse range of housing materials to ensure compatibility with various sample types. MultiScreen® filtration plates are offered in a broad selection of membrane filters with both sterile and non-sterile options.
MultiScreen®~HTS~plates are specifically designed for high throughput use with automated workstations. Firm sidewalls improve handling, and ample surfaces are provided for barcode label placement. Individual wells are sealed to prevent crosstalk arising from incubation. The patented underdrain is removable to provide easy access to the filters. MultiScreen® HTS+ filter plates have a unique, nylon mesh backing for enhanced washing, reducing background and improving signal-to-noise ratios. Filter plates are available in 96-and 384-well formats, and are available in a broad selection of membranes and plastics.
MultiScreen® Classic plates are specifically designed for assays requiring removal of the underdrain and access to membranes. Flexible plate base material can be removed by hand for low throughput assays. Individual wells are sealed to prevent crosstalk arising from incubation. Filter plates are available in 96-well format and are available in a broad selection of membranes and plastics.
For sample preparation, protein precipitation with solvents, bead cleavage assays, and quantitative filtrate transfer for analysis, we recommend MultiScreen® Solvinert™ filter plates. These plates contain hydrophilic or hydrophobic PTFE membranes which ensure low extractables, low undesirable binding, and high analyte recovery.
MultiScreen® MESH systems use a 96-well nylon mesh-bottom filter plate, and constitute a complete system for target screening and other critical applications by evaluating new compounds using multicellular organisms as the in vivo model. These systems are routinely used in pharmaceutical and agropharma discovery for assays measuring cytotoxicity, paralysis, and death. Plates are constructed of optically-clear plastic to facilitate imaging.
The MultiScreen® -MIC filter plate provides a reliable, versatile platform for a range of cell-based screening assays including migration, invasion, chemotaxis, co-culture, angiogenesis, and transmigration. Plates and kits are available in a wide range of membrane pore sizes to accommodate assays with adherent or suspension cell lines and to support cell growth for transmigration and coculture assays. The plates are provided sterile to permit longer incubation times and enable assay setup and analysis in the same device.
MultiScreen® PCR filter plates exploit size exclusion principles for purifying products of polymerase chain reaction (PCR), bacterial artificial chromosome (BAC) preparations, and plasmid preparations, as well sequencing reaction cleanup. These plates offer filters for fast, automatable, high-throughput PCR purification. Plates are provided in 96- and 384-well formats, including a micro-96-well format for purification of smaller volume PCR product samples.
MultiScreen® Microplates are available as non-sterile, 96-well & 384-well microplates in clear, white, black, or natural. Polystyrene microplates are commonly used for biochemical assays, including colorimetric, luminescent, and fluorescent applications - for example, Bradford-Lowry or luciferase assays - routinely performed on microplate readers. Polypropylene microplates are commonly used for storage of chemicals, nucleic acids, and proteins. These microplates can also be used for colorimetric assays and basic biochemical reactions.
Polystyrene is a highly clear polymer with excellent optical properties which makes it ideal for precise optical measurements. Polystyrene is also characterized by its ability to bind biomolecules, such as proteins, and it is therefore often used for manufacturing immunological products. Polystyrene MultiScreen® HTS Microplates are currently available as non-sterile, 96-well microplates in clear, white, or black. These microplates are commonly used for biochemical assays, including colorimetric, luminescent, and fluorescent applications - for example, Bradford-Lowry or luciferase assays - routinely performed on microplate readers.
Polypropylene is characterized by its excellent chemical and thermal stability. It is the ideal polymer for storage microplates. Polar molecules, such as proteins or DNA, bind less to polypropylene than to polystyrene. Polypropylene MultiScreen® HTS Microplates are currently available as non-sterile microplates in natural 96-well & 384-well formats. These microplates are commonly used for storage of chemicals, nucleic acids, and proteins. These microplates can also be used for colorimetric assays and basic biochemical reactions.
Enzyme-Linked Immunosorbent Assay (ELISA) is a plate-based assay technique designed for detecting and quantifying soluble substances such as peptides, proteins, antibodies, and hormones. MultiScreen® HTS ELISA Microplates are made of polypropylene and available in 96-well or 8-well strip formats. 8-well strip formats allow for single wells or strips of wells to be used in an assay rather than consuming the entire microplate. These are available with medium or high binding surfaces to best suit the needs of the application and molecules involved.
MultiScreen® vacuum manifolds use DirectStackTM technology to improve filter-based assay performance and reliability, enabling plate-on-plate stacking which eliminates gaps between flow directors and receiver wells in applications that require filtrate collection. A variety of accessories are available to optimize workflows for radioactivity, chromatography, and sample collection.