Mobius® fluid transport and storage systems

Expertise in Folate Production

With more than 70 years of expertise in high-purity folate production, we offer a complete portfolio of reduced folates for both pharmaceutical and nutritional applications. Explore our folate capabilities below and contact us to find the right folate suited for your work.

Product Listings

Folate Applications

Folates play an essential role for the human body from preconception until old age and are a critical factor in many important areas of health and well-being.

Folate Portfolio


Arcofolin® is the latest innovation standard for folate supplementation. As the monosodium salt of L-5-methyltetrahydrofolic acid, it is the pure and crystalline form of the naturally occurring predominant form of folate.

Achieving a sufficient intake level of folate can be difficult. With large amounts of native folate being lost during processing and cooking, humans benefit from folate supplementation. Arcofolin® supplementation is critical to achieving a balanced folate intake and protecting from health risks associated with low levels of folate. When it comes to folates, with Arcofolin® - it can't get better!

The benefits of Arcofolin® L-methylfolate include:


Metafolin® offers a more bioavailable alternative to folic acid in the form of our legacy manufactured calcium salt of L-5-methyltetrahydrofolic acid. Produced under cGMP conditions with high quality standards, Metafolin® has an extensive regulatory record and broad industry usage since its introduction in 2001. It fulfills the specifications of the United States Pharmacopoeia (USP).

Contact us to learn more about how bioavailable methylfolates can benefit your work in nutritional supplementation.

API Folates

Calcium Folinate / Leucovorin Calcium
Our Calcium Folinate offerings are produced under cGMP conditions with high regulatory oversight. We offer two forms of Calcium Folinate:

Calcium Folinate serve three main clinical applications:

  1. First line treatment for colorectal cancer: In combination with the anticancer drug 5- fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy;
  2. Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate;
  3. Treatment of anemia caused by folate deficiency

Our Calcium Folinate fulfills specifications that are tighter than the requirement of the European or U.S. Pharmacopoeia. Furthermore, we maintain a U.S. Drug Master File (DMF), a certificate of Suitability (CEP) and a Common Technical Document (CTD) in Japan. Additional documents such as a Kosher, non-GMO, or TSE-certificate among others are also available.

Calcium Levofolinate Pentahydrate
As the first company worldwide to produce Calcium Levofolinate Pentahydrate (Levoleucovorin Calcium Pentahydrate), (6S)-5-Formytetrahydrofolic acid, Calcium Salt in commercial quantities, we are committed to delivering the highest product quality. Produced under cGMP conditions with high quality standards, this drug substance is approved in Europe, Japan, and the U.S. We maintain a certificate of Suitability (CEP) and a Common Technical Document (CTD) in Japan. Additional documents such as a Kosher, non-GMO, or TSE-certificate are also available.

Contact us to learn more about how our folates can benefit your pharmaceutical work.

Folate Research Partnerships

As an industry leader for commercial production of reduced folates, we continue to evolve and innovate. We collaborate with leading research institutes and universities and support research with high-quality folates. Contact us to discuss research partnership opportunities.

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