Downstream purification in bioprocessing includes one or more chromatographic separation steps to purify your molecule and remove impurities. Our broad chromatography portfolio includes resins, membranes, columns, and systems that work seamlessly together to simplify your workflow from process development to production scale.
Backed by unparalleled applications expertise and comprehensive support, we provide the confidence you need to tackle any chromatography challenge in your downstream process to increase productivity and improve efficiency.
Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale. From screening to large-scale production, our columns provide robust and consistent performance with the processing flexibility you need.
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.
Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.
Membrane chromatography is a highly productive downstream purification technology used for capture through polishing. Natrix® chromatography membrane is a single-use solution which improves process economics and facility utilization when compared to traditional membrane adsorbers.
Ion exchange (IEX) chromatography separates biomolecules based on difference in charge between the target molecule and chromatography resin. Widely used in bioprocessing, our anion and cation exchange chromatography resins efficiently purify mAbs, recombinant proteins, vaccines, plasma, and other therapeutic molecules.
Size exclusion chromatography (SEC) is a purification method used for separating substances based on their molecular size. Widely used in commercial bioseparation processes, size exclusion chromatography is a versatile technique because buffer composition does not impact separation effectiveness.
High-performance liquid chromatography (HPLC) is a crucial step in the separation and purification of complex biomolecules. Our broad portfolio of normal-phase and reverse-phase silica gel resins economically delivers the excellent separation and high purity you need.