Clarification Depth Filters & Pretreatment Solutions
Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris, and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices.
Section Overview
Products
Millistak+® HC Pro Filters
MILLISTAK+® HC PRO FILTERS
These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications and are available in Pod format for easy set up and use.
These filters are cleaner and have improved lot to lot consistency as compared to diatomaceous earth (DE) and cellulose (CE) based filter media.
Millistak+® Depth Filters
Millistak+® Depth Filters
These filters are offered in both Pod and lenticular formats.
- Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
- Millistak+® CR40 filters contain activated carbon in a cellulose matrix and enhance clearance of HCP and impurities in polishing applications.
- Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder for primary or secondary clarification applications.
- Millistak+® CE filters are single layer clarification filters containing cellulose for coarse, primary clarification applications.
Clarisolve® Depth Filters and Flocculation Polymers
Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated cell culture harvests.
- pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.
Support for Qualification, Risk Assessment, and Process Optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Product Resources
- Guide: Clarification Portfolio
Single and multi-use products for the successful development and implementation of robust clarification processes.
- Brochure: Millistak+® Family and Clarisolve®
Discover Millistak+® family and Clarisolve® depth filters at a glance.
- Data Sheet: Millistak+® HC Pro Synthetic Depth Filters
Fully synthetic depth filters for clarification and downstream filtration applications.
- Data Sheet: Millistak+® Pod Carbon Depth Filter Media System
Millistak+® carbon (CR) depth filter media incorporates activated carbon for the removal of color and trace contaminants.
- Data Sheet: Clarification Solutions for Pre-treated Feed Streams
Together, the pDADMAC polymer, and Clarisolve® depth filters provide an effective solution for harvesting high cell density cultures that can be easily incorporated into current clarification platforms.
- Data Sheet: Millistak+® Pod Disposable Depth Filter System
High-Performance Pod Filters are Ideal for Primary and Secondary Clarification in Lab, Pilot and Process-scale Applications.
- Article: pDADMAC Flocculation in Monoclonal Antibody Production Processes – Overcoming Regulatory Challenges with Quality Risk Management
Flocculants, like pDADMAC, remove cell debris during downstream monoclonal antibody production, but their adoption has been difficult due to perceived regulatory concerns.
- Application Note: Scalability Studies for Millistak+® HC and Millistak+® HC Pro Micro 20 Devices
Scale-up and Scale-down Primary and Secondary Clarification with C0HC, D0HC, X0HC, C0SP, D0SP, and X0SP Media Grades.
- Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing
A Virus-Like Particle (VLP) is a biological nanoparticle which consists of the protective protein shell of a virus.
- Guide: Millistak+® Pod Disposable Depth Filter Performance
This is a reference document to provide assistance in evaluating and validating Millistak+® Pod depth filters for clarification applications.
- Application Note: Millistak+® Activated Carbon for mAb Downstream Purification
This document demonstrates that Millistak+® Activated Carbon has the ability to reduce HCP present in Protein A elution pools under various solution conditions.
- Article: Membrane Filtration: Efficient Particle Retention and Bioburden Reduction in Bioprocessing Fluid Streams
Some prefilters reduce bioburden and can be used as a cost-effective alternative to sterilizing filters for bioburden control in bioprocessing.
- Application Note: DADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
pDADMAC improves the removal of contaminants by driving the charged flocculation of the negatively charged entities.
- User Guide: Pod Depth Filters
This document is a comprehensive guide for users of pod depth filters.
- User Guide: μPod® Filters
This document is a comprehensive guide for users of µPod® Filters.
How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.
pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.
Join to hear case studies on effective separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing mAbs.
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