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Clarification Depth Filters & Pretreatment Solutions

Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices.

Millistak+® HC Pro Filters

Millistak+® HC Pro Filters

MILLISTAK+® HC PRO FILTERS

These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications.

Millistak+® Depth Filters

Millistak+® Depth Filters

Millistak+® Depth Filters

These filters are offered in both Pod and lenticular formats.

  • Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
  • Millistak+® Carbon offers enhanced impurity clearance for turbidity reduction and polishing.
  • Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder.
  • Millistak+® CE filters are single layer clarification filters containing cellulose.
Clarisolve® depth filters and polymers

Clarisolve® Depth Filters and Flocculation Polymers

Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated cell culture harvests.

  • pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.

Support for Qualification, Risk Assessment, and Process Optimization

Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

Find the right filter for your application.

Related Product Resources

mAb Expression, Purification, and Formulation

mAbsizer™ Calculator

Product Selection

Guide: Clarification Portfolio Guide
Flyer: Millistak+® Family and Clarisolve® Depth Filters at a Glance
Flyer: Clarification of Mammalian Cell Cultures by Depth Filtration

Product Specifications

Data Sheet: Millistak+® HC Pro Synthetic Depth Filters
Data Sheet: Millistak+® Pod Carbon Depth Filter Media System
Data Sheet: Clarification Solutions for Pre-treated Feed Streams
Data Sheet: Millistak+® Pod Disposable Depth Filter System

Product Operations

Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing
Article: Complete Clarification Solution for Processing High Density Cell Culture
Article: Selection of Clarification Methods for Improved Downstream Performance and Economics
Article: Evolving Clarification Strategies to Meet New Challenges
Article: Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes
Article: Development of a Novel and Efficient Cell Culture Flocculation Process Using a Stimulus Responsive Polymer to Streamline Antibody Purification Processes
Guide: Millistak+® Pod Disposable Depth Filter Performance
Application Note: Millistak+® Activated Carbon for mAb Downstream Purification
Application Note: pDADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
User Guide: Pod Depth Filters
User Guide: μPod® Filters

Products

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Product Number
Product Description
Pricing
CS20MS02H1
Clarisolve® Depth Filters, High-density cell cultures
CS20MS05F1-X
Clarisolve® Depth Filters, High-density cell cultures
MD0HC10FS1
Millistak+® HC Pod Depth Filter, D0HC, cellulose, filtration area 1.1 m2, hydrophilic
MD0HC054H1
Millistak+® HC Pod Depth Filter, D0HC, cellulose, filtration area 0.054 m2, hydrophilic
MD0HC027H1
Millistak+® HC Pod Depth Filter, D0HC, cellulose, filtration area 0.027 m2, hydrophilic
MX0HC027H1
Millistak+® Pod Depth Filter, X0HC, cellulose, filtration area 0.027 m2, hydrophilic
MP0DSYS1B
Process Scale Holders, for use with Pod Filters, 316L stainless steel
MD0SP027H1
Millistak+® HC Pro Pod Depth Filter, D0SP, filtration area 0.027 m2, hydrophilic
MF0HC05FS1
Millistak+® Pod Depth Filter, F0HC, cellulose, filtration area 0.55 m2, hydrophilic
CS20MS01F1-X
Clarisolve® Depth Filters, High-density cell cultures
CS40MS02H1
Clarisolve® Depth Filters, High-density cell cultures
MX0HC23CL3
Millistak+® Depth Filter in μPOD format, X0HC, cellulose fiber, filtration area 0.0023 m2, hydrophilic
MC0SP23CL3
Millistak+® HC Pro Pod Depth Filter, C0SP, filtration area 23 cm2, hydrophilic
MC0HC054H1
Millistak+® HC Pod Depth Filter, C0HC, cellulose, filtration area 0.054 m2, hydrophilic
MP0DADAPT
Disposable Adapter Kit 3 through adapters, 3 blind adapters
MD0HC01FS1
Millistak+® HC Pod Depth Filter, D0HC, cellulose, filtration area 0.11 m2, hydrophilic
MX0HC054H1
Millistak+® Pod Depth Filter, X0HC, cellulose, filtration area 0.054 m2, hydrophilic
MX0HC01FS1
Millistak+® HC Pro Pod Depth Filter, X0HC, cellulose, filtration area 0.11 m2, hydrophilic
MA1HC027H1
Millistak+® HC Pod Depth Filter, A1HC, cellulose, filtration area 0.027 m2, hydrophilic
MX0HC10FS1
Millistak+® HC Pro Pod Depth Filter, X0HC, cellulose, filtration area 1.1 m2, hydrophilic
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Related Product Categories
Clarification Prefilters
Clarification prefilters remove particles and microorganisms from pharma and biopharma process streams. Learn how our clarification prefilters remove insoluble impurities early in your process, protecting critical downstream operations.
Clarification Filter Holders and Systems for Bioprocessing
Our flexible hardware and systems for disposable depth filters are ideal for clarification at pilot and process scales, featuring the modular Pod device that enables scale-up and scale-down within the same footprint.
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Related Services
Training & Education
Pharmaceutical and biopharmaceutical manufacturers can enhance their skill sets with practical, hands-on training courses in-person or streamed live from our M Lab™ Collaboration Centers.
Customer Collaboration Labs for Bioprocessing Optimization
Optimize your biomanufacturing at M Lab™ Collaboration Centers, where customers explore, learn and collaborate to solve their toughest bioprocess challenges.
Emprove® Filters and Single-Use Components
Answering industry-wide demand for increased transparency, our Emprove® Filter and Single-use Components portfolio helps biopharmaceutical manufacturers advance their product development with confidence.

Highlights

Webinar: Best Practices for Process Development Using Small-scale Millistak+<sup>®</sup> Filters
Webinar: Best Practices for Process Development Using Small-scale Millistak+® Filters

How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.

Webinar: Clarification of Mammalian Cell Culture Feed Streams Using a Cationic Flocculant, pDADMAC, and Clarisolve<sup>®</sup> Depth Filters
Webinar: Clarification of Mammalian Cell Culture Feed Streams Using a Cationic Flocculant, pDADMAC, and Clarisolve® Depth Filters

pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.

Webinar: Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications
Webinar: Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications

Join to hear case studies on effective separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing mAbs.

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