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Tangential Flow Filtration Devices

From single-use to multi-use, our tangential flow filtration (TFF) products are ideal for pharma and biopharma manufacturing.

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Product Number
Product Description
Pricing
P2GVPPV20
Pellicon® 2 Maxi Filter Module, filtration area 2 m2, pore size 0.22 μm
P2C300C25
Pellicon® 2 Maxi Ultrafiltration Module, filtration area 2.5 m2, NMWCO 300 kDa
P3C030C10
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 1.14 m2, NMWCO 30 kDa
P3C030D05
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 0.57 m2, NMWCO 30 kDa
P3C030C00
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 88 cm2, NMWCO 30 kDa
P3C030D00
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 88 cm2, NMWCO 30 kDa
P3C030C01
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 0.11 m2, NMWCO 30 kDa
P3C030D01
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 0.11 m2, NMWCO 30 kDa
P3C010C01
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 0.11 m2, NMWCO 10 kDa
P3C030C05
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 0.57 m2, NMWCO 30 kDa
PXC300C50
Pellicon® XL Cassette with Ultracel® Membrane, filtration area 50 cm2, NMWCO 300 kDa
P3B030A01
Pellicon® 3 Cassette with Biomax® Membrane, 30kDa, A Screen, 0.11 m2
P3C010C00
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 88 cm2, NMWCO 10 kDa
P2B100C25
Pellicon® 2 Maxi Ultrafiltration Biomax® Module, filtration area 2.5 m2, NMWCO 100 kDa
P2C300C01
Pellicon® 2 Mini Ultrafiltration Module, filtration area 0.1 m2, NMWCO 300 kDa
P3C030D10
Pellicon® 3 Cassette with Ultracel® Membrane, filtration area 1.14 m2, NMWCO 30 kDa
P2C01MC25
Pellicon® 2 Maxi Ultrafiltration Module, filtration area 2.5 m2, NMWCO 1000 kDa
P2B300C25
Pellicon® 2 Maxi Ultrafiltration Biomax® Module, filtration area 2.5 m2, NMWCO 300 kDa
P2B100C01
Pellicon® 2 Mini Ultrafiltration Biomax® Module, filtration area 0.1 m2, NMWCO 100 kDa
P2B01MC25
Pellicon® 2 Maxi Ultrafiltration Biomax® Module, filtration area 2.5 m2, NMWCO 1000 kDa
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Pellicon® single-pass TFF is a convenient way to reduce volumes to eliminate tank bottlenecks, reduce the size of subsequent steps, concentrate with inline buffer addition for desalting, and facilitate high final concentrations with high product recovery

Pellicon® Single-Pass TFF

Single-pass TFF with our Pellicon® capsules and cassettes streamlines processing by concentrating process streams without the recirculation of traditional TFF. This is a simple way to increase capacity, concentration, and product recovery while improving footprint. This versatile application also enables continuous and intensified processing, in which in-line volume reduction is coupled to other process steps.

Our single-use Pellicon® Capsules can be ready to perform ultrafiltration and diafiltration of mAbs and ADCs in minutes

Pellicon® Capsules

Pellicon® Capsules with Ultracel® membrane are designed for streamlined ultrafiltration and diafiltration of biopharmaceuticals, offering ease of use and process flexibility. This innovative capsule is a true single-use TFF device with a unique plug-and-play, holderless design that comes ready to process in minutes.

Pellicon® 3 cassettes deliver high protein yield with consistent purity and quality for a variety of drug products

Pellicon® 3 Cassettes

Pellicon® 3 cassettes deliver high protein yield and consistent performance while offering broad chemical compatibility. They are available with Ultracel® and Biomax® membranes for different processing needs, including mAbs, plasma, insulin, peptides, and vaccines. To overcome high viscosity challenges, our Pellicon® 3 cassettes with D screen are optimized to achieve higher protein concentrations.

Pellicon® 2 Cassettes

Pellicon® 2 cassettes are ideal for the ultrafiltration and diafiltration of biologics including concentration, desalting, and buffer exchange of polysaccharides, virus suspensions, and protein solutions. Our Ultracel® and Biomax® membranes offer efficient ultrafiltration while Durapore® membrane is best suited for microfiltration.

Pellicon® XL 50 Cassettes

Pellicon® XL 50 cassettes couple our ultrafiltration and microfiltration membranes with linear scalability for process development or small-volume processing.

Prostak™ Microfiltration Modules

Prostak™ microfiltration modules provide robust construction, reliable performance, and steam-in-place capability, making them suitable for clarification, cell harvest, and multi-use perfusion. The low hold-up volume and open channel design allow high product recovery and gentle flow path for processing shear-sensitive materials.

Support for Qualification, Risk Assessment, and Process Optimization

Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

Related Product Resources

mAb Expression, Purification, and Formulation

mAbsizer™ Calculator

Single-use Product Specifications

Data Sheet: Pellicon® Capsules with Ultracel® Membrane

Multi-use Product Specifications

Data Sheet: Pellicon® 3 Cassettes with Ultracel® Membrane
Data Sheet: Pellicon® 3 Cassettes with Biomax® Membrane
Data Sheet: Pellicon® 2 Filters and Holders
Data Sheet: Prostak™ Microfiltration Modules
Data Sheet: Pellicon® XL 50 Cassettes

General Product Specifications

Data Sheet: Pellicon® Single-Pass Tangential Flow Filtration
Data Sheet: Ultracel® Membranes
Data Sheet: Biomax® Membranes

Single-use Operations

Performance Guide: Pellicon® Capsules with Ultracel® Membrane Performance Guide 
 Application Note: Pellicon® Capsules for Single-use Tangential Flow Filtration 
Application Note: Pellicon® Capsules for Ultrafiltration/Diafiltration in the Antibody Drug Conjugate Manufacturing Process 
Article: ADC Review: Trial of High Efficiency TFF Capsule Prototype for ADC Purification 
Article: European Biopharmaceutical Review: Novel TFF Capsule Evaluation

Multi-use Operations

Performance Guide: Pellicon® 3 Cassettes with Ultracel® Membrane Performance Guide
Performance Guide: Pellicon® 3 Cassettes with Biomax® Membrane Performance Guide
Application Note: Performance Evaluation and Cleanability Study using Pellicon® 3 Cassettes with 30 kD Biomax® and Ultracel® Ultrafiltration Membranes  
Application Note: Pellicon® 3 Cassettes with High Viscosity Feed Screen

Intensified Operations

Application Note: Process Optimization and Scalability Evaluation of Pellicon® Capsules for Single-pass Tangential Flow Filtration of mAb-Based Biomolecules 
Article: Adding Versatility with Single-Pass TFF 
White Paper: Streamlining Bioprocessing Using Pellicon® Cassettes for Single-pass Operation

Related Product Categories
Tangential Flow Filtration Holders & Systems
Our tangential flow (crossflow) filtration systems are engineered for low hold-up volume, maximum volume concentration, and optimal product recovery in single-use and multi-use applications from process development to large-scale manufacturing, with compatible holders available for expendables.
Downstream Process & Formulation Chemicals
Our broad portfolio of downstream chemicals simplifies raw material specification with optimized quality attributes for all your applications – while providing industry-leading support and documentation to help navigate regulatory challenges, manage risks, and improve processes.
Buffers & pH Adjusters
Our broad portfolio of buffer materials manufactured according to GMP guidelines includes excipients specifically for drug formulation and manufacturing, including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters with regulatory support.
Related Applications
Closed Processing for Biomanufacturing
Learn how closed processing can mitigate contamination risks, reduce costly and environmentally demanding cleanroom control measures, and maximize facility utilization.
Antibody-Drug Conjugate (ADC) Manufacturing
Antibody-drug conjugation (ADC) technology uses monoclonal antibodies (mAbs) to deliver potent, highly active pharmaceutical ingredients (HPAPIs) to targeted cells. Learn about processes and areas of expertise required to advance your ADC to market.
mAb Downstream Processing
Optimization of the downstream steps in mAb processing is critical to ensuring product quality, yield, and sterility. Learn how to leverage various products, services, and solutions to get the most out of every step.
Detecting and Removing Aggregates
Protein aggregates are a concern throughout both upstream and downstream mAb manufacturing. Learn how to minimize aggregate formation to maximize process efficiency and robustness.
Pharma & Biopharma Startup Hub
Your new molecule or therapy begins its journey here. Find solutions and resources to navigate your path to successful drug discovery, development, and commercialization.
Viral Vector Downstream Processing
Demand for new gene therapies is challenging manufacturers to accelerate development. By replacing legacy purification technologies with more scalable alternatives, downstream operations can produce greater economies while delivering higher yield and throughput.
Blood Plasma Fractionation
Consistent, reliable performance is key to blood plasma fractionation, posing challenges to improve yield, maintain process economics, and manage regulatory requirements. Learn how the right partner can help fractionators to better serve patients globally with enhanced IgG, albumin, and Factor VIII products.
Vaccine Manufacturing
From early phase development, through downstream purification to large scale vaccine production: learn more about vaccine process development and application expertise.
Related Services
Emprove® Program
Emprove® Program: The smart way to master compliance and control. Complementing our product portfolio, the Emprove® Program provides convenient access to reliable technical, regulatory and supply information in Emprove® Dossiers to support your risk assessment continuum.
Training & Education
Pharmaceutical and biopharmaceutical manufacturers can enhance their skill sets with practical, hands-on training courses in-person or streamed live from our M Lab™ Collaboration Centers.
Customer Collaboration Labs for Bioprocessing Optimization
Optimize your biomanufacturing at M Lab™ Collaboration Centers, where customers explore, learn and collaborate to solve their toughest bioprocess challenges.

Highlights

Challenges and Options in High Viscosity Tangential Flow Filtration
Challenges and Options in High Viscosity Tangential Flow Filtration

An overview of TFF solutions for achieving high viscosity of monoclonal antibodies and plasma IgG, and strategies for reliable cycle-to-cycle cleaning.

Using Single-use Technology to Enable Single-pass Tangential Flow Filtration
Using Single-use Technology to Enable Single-pass Tangential Flow Filtration

An overview of single-use TFF capsules for single-pass tangential flow filtration (SPTFF) of mAbs and other therapeutic proteins.

Intensified mAb Polishing: Linking Single Pass Tangential Flow Filtration with Anion Exchange Chromatography
Intensified mAb Polishing: Linking Single Pass Tangential Flow Filtration with Anion Exchange Chromatography

A new approach which combines SPTFF with Eshmuno® Q chromatography resin for intensified mAb polishing.



Pellicon® Capsule How Is It Made and How Does it Work?
See what makes the Pellicon® Capsule a true single-use TFF device that comes ready to process mAbs and ADCs in minutes.
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