Search Within


Applied Filters:
Showing 1-30 of 111 results for "06-863" within Papers
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.
Jacob B Hansen, Claus J?rgensen, Rasmus K Petersen, Philip Hallenborg, Rita De Matteis et al.
Proceedings of the National Academy of Sciences of the USA null
Dilip K Deb et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(5), 2065-2075 (2017-02-06)
Hyperglycemia is a major pathogenic factor that promotes diabetic nephropathy, but the underlying mechanism remains incompletely understood. Here, we show that high glucose induced cAMP response element-binding protein (CREB)-binding protein (CBP)-mediated H3K9/14 hyperacetylation in approximately 5000 gene promoters in glomerular
Maria Domenica Castellone et al.
Cancer research, 69(5), 1867-1876 (2009-02-19)
RET/papillary thyroid carcinoma (RET/PTC) oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase domain with protein dimerization motifs encoded by heterologous genes. Here, we show that RET/PTC stimulates the beta-catenin pathway. By stimulating PI3K/AKT and Ras/extracellular signal-regulated
Julian Stürznickel et al.
Scientific reports, 12(1), 16491-16491 (2022-10-04)
Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of intra- and extrahepatic bile ducts. Osteoporosis is a frequent comorbidity in PSC, and we could previously demonstrate that IL17-dependent activation of bone
Massimo Sabbatini et al.
American journal of physiology. Renal physiology, 306(10), F1243-F1250 (2014-03-22)
Both experimental and clinical studies have suggested that any potential treatment of polycystic kidney disease (PKD) should start early and last for a long time to be effective, with unavoidable side reactions and considerable costs. The aim of the present
Igor Martianov et al.
BMC genomics, 11, 530-530 (2010-10-06)
CREB and CREM are closely related factors that regulate transcription in response to various stress, metabolic and developmental signals. The CREMτ activator isoform is selectively expressed in haploid spermatids and plays an essential role in murine spermiogenesis. We have used
Marsha L DeSmet et al.
The Journal of steroid biochemistry and molecular biology, 173, 194-201 (2017-01-21)
High vitamin D status is associated with reduced colon cancer risk but these studies ignore the diversity in the molecular etiology of colon cancer. RAS activating mutations are common in colon cancer and they activate pro-proliferative signaling pathways. We examined
Monia Giampuzzi et al.
Biochimica et biophysica acta, 1745(3), 370-381 (2005-06-11)
Lysyl oxidase is the enzyme that is essential for collagen and elastin cross-linking. Previous investigations showed that lysyl oxidase is down-regulated in many human tumors and ras-transformed cells. Recently, we proved that antisense down-regulation of lysyl oxidase in NRK-49F cells
Matteo Rossi et al.
Nucleic acids research, 36(22), 7168-7180 (2008-11-19)
PPM1D (Wip1), a type PP2C phosphatase, is expressed at low levels in most normal tissues but is overexpressed in several types of cancers. In cells containing wild-type p53, the levels of PPM1D mRNA and protein increase following exposure to genotoxic
Kelli A McDowell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(22), 7453-7465 (2010-06-04)
Transcription factors are a key point of convergence between the cell-intrinsic and extracellular signals that guide synaptic development and brain plasticity. Calcium-response factor (CaRF) is a unique transcription factor first identified as a binding protein for a calcium-response element in
J W Dalley et al.
The European journal of neuroscience, 11(4), 1265-1274 (1999-04-02)
The present study investigated the effects of excitotoxic lesions of the prefrontal cortex (PFC) on dopamine (DA) and excitatory amino acid (EAA) function in the nucleus accumbens core using in vivo microdialysis in freely moving rats. As a postsynaptic marker
Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells.
Cheng, J; Watkins, SC; Walker, WH
Endocrinology null
Jürgen Tuvikene et al.
eLife, 10 (2021-02-10)
Brain-derived neurotrophic factor (BDNF) controls the survival, growth, and function of neurons both during the development and in the adult nervous system. Bdnf is transcribed from several distinct promoters generating transcripts with alternative 5' exons. Bdnf transcripts initiated at the
José R Naranjo et al.
The Journal of clinical investigation, 126(2), 627-638 (2016-01-12)
Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein
J R Lundblad et al.
The Journal of biological chemistry, 273(30), 19251-19259 (1998-07-21)
Tax-1, the transcriptional activation protein of human T-cell leukemia virus-1, increases transcription from the human T-cell leukemia virus-1 long terminal repeat and specific cellular promoters through interactions with cellular DNA-binding proteins. The Tax response elements (TxREs) of the long terminal
Bin Liang et al.
The Journal of biological chemistry, 285(36), 27737-27744 (2010-07-03)
Abnormal activation of calpain is implicated in synaptic dysfunction and participates in neuronal death in Alzheimer disease (AD) and other neurological disorders. Pharmacological inhibition of calpain has been shown to improve memory and synaptic transmission in the mouse model of
Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion.
A Zaheer, M A Yorek, R Lim
Neurochemical Research null
Mien-Sheng Chu et al.
Cellular signalling, 18(4), 519-530 (2005-08-16)
Recent in vivo transplantation studies have shown that mesenchymal stem cells (MSCs) were able to differentiate into mesoderm-derived cell types as well as cells with neuroectodermal characteristics, suggesting that transdifferentiation occurs in the mammalian system. We have reported an immortalized
Cooperative regulation of endogenous cAMP-response element binding protein and CCAAT/enhancer-binding protein beta in GH-stimulated c-fos expression.
Cui, TX; Kwok, R; Schwartz, J
The Journal of Endocrinology null
Bingting Chen et al.
Gut microbes, 15(1), 2192155-2192155 (2023-03-28)
Accumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxycholic acid (GUDCA) positively regulates gut microbiota by altering bile
Yirong Yuan et al.
Journal of psychopharmacology (Oxford, England), 34(7), 726-736 (2020-04-21)
trans-Resveratrol has been extensively investigated for its anti-inflammatory, antioxidant, and anti-psychiatric properties. However, whether it could rescue posttraumatic stress disorder-like stress-induced pain abnormality is unknown. The present study examined the effects of trans-resveratrol on anxiety-like behavior and neuropathic pain induced
Huaibo Zhang et al.
Scientific reports, 8(1), 10376-10376 (2018-07-12)
Binge alcohol drinking in adolescence leads to increased risk for alcohol use and other psychiatric disorders in adulthood. The transcription factor cAMP-response element binding (CREB) protein is involved in the neuronal response to adult ethanol exposure, but its role in
Zirong Chen et al.
Oncogene, 37(14), 1885-1895 (2018-01-23)
Mucoepidermoid carcinoma (MEC) arises in many glandular tissues and contributes to the most common malignant salivary gland cancers. MEC is specifically associated with a unique t(11;19) translocation and the resulting CRTC1-MAML2 fusion is a major oncogenic driver for MEC initiation
Keith Quincy Tanis et al.
Biological psychiatry, 63(7), 710-720 (2007-10-16)
The transcription factor cyclic adenosine monophosphate response element binding protein (CREB) orchestrates diverse neurobiological processes including cell differentiation, survival, and plasticity. Alterations in CREB-mediated transcription have been implicated in numerous central nervous system (CNS) disorders including depression, anxiety, addiction, and
Serban San-Marina et al.
Biochimica et biophysica acta, 1783(3), 503-517 (2007-12-28)
The basic helix-loop-helix (bHLH) transcription factor family contains key regulators of cellular proliferation and differentiation as well as the suspected oncoproteins Tal1 and Lyl1. Tal1 and Lyl1 are aberrantly over-expressed in leukemia as a result of chromosomal translocations, or other
Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.
Lemasson, I; Polakowski, NJ; Laybourn, PJ; Nyborg, JK
The Journal of Biological Chemistry null
MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.
Deng, JV; Wan, Y; Wang, X; Cohen, S; Wetsel, WC; Greenberg, ME; Kenny, PJ; Calakos, N; West, AE
The Journal of Neuroscience null
M Caivano et al.
The Journal of biological chemistry, 276(52), 48693-48701 (2001-10-23)
Prostaglandins are important mediators of activated macrophage functions, and their inducible synthesis is mediated by cyclooxygenase-2 (COX-2). Here, we make use of the murine macrophage cells RAW264 as well as of immortalized macrophages derived from mice deficient for the transcription
Ying-Cong Yu et al.
Frontiers in cellular neuroscience, 13, 30-30 (2019-02-26)
Irritable bowel syndrome (IBS) is at high risk of co-morbid depression and anxiety, which reduces patients' quality of life and increases the burden of health care costs. However, the pathophysiological mechanisms responsible for IBS still remain unknown. This study investigated
Qian Bu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(13), 3671-3685 (2017-03-09)
Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene. To facilitate the study of cellular mechanisms in human cells, we established several human stem cell lines: human embryonic stem cell (hESC) line carrying the
Page 1 of 4