Calibration, qualification, and validation

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Determination of Stevioside and Rebaudioside A in Stevia leaves, beverages and food additives using HPTLC-MS

HPTLC-MS was used to analyze stevioside and rebaudioside in artificial sweeteners, stevia plants, cola and isotonic drinks with a minimum of sample preparation.

Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS

Calculating Your Working Tolerance: A Guideline

Guideline to calculate your working tolerance - Certified Standard Solutions (CRM)

Quantification of Infliximab in Human Serum by LC-MS/MS Using A Full-Length Stable Isotope Labeled Internal Standard

Infliximab, a chimeric monoclonal antibody, is used to treat rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and other autoimmune diseases.

High-Performance Thin-Layer Chromatography: A Fast and Efficient Fingerprint Analysis Method for Medicinal Plants

In this article we present several HPTLC applications and analytical standards for ginsenosides.

Enzymatic Method for Determining Branched Chain Amino Acids (BCAA Assay)

Assay protocol for the colorimetric detection of Branched Chain Amino Acids (BCAA) in biological samples using the alanine assay kit.

Extractables Studies of Single-Use Equipment Immediate Identification and Quantification of Unknown Extractables by GC/MS with a Certified Reference Material Mix for Extractables and Leachables

Identification and quantification of the most common extractables originating from single-use equipment by GC/MS and an Extractables and Leachables Screening Standard.

Quantification of Bitter Acids in Hops by Thin Layer Chromatography

HPTLC separation followed by UV detection of the bitter acid content in various hop samples.

Biodiesel

Learn more about Biodiesel as a renewable, alternative diesel fuel produced from vegetable oils, animal fats, or recycled restaurant grease.

Importance of Volumetric Solution Standardization

The titer determination or standardization of a titration solution is essential for accurate and reliable titration results.

Analysis of Pesticides in Baby Food by Solid Phase Microextraction (SPME) Using a New Overcoated Fiber

A direct immersion SPME method using a new overcoated SPME fiber was developed for the extraction of pesticides from pureed prune baby food.

Optimizing for High Throughput Analysis of Cannabinoids in a Variety of Matrices Using Ascentis® Express C18 Column

A complete workflow for the HPLC separation of 17 cannabinoids in different cannabis products using Ascentis® Express C18 Column in a shorter run time with retention time stability. Learn more here.

Vitamin D epi-Metabolites Separated with HybridSPE-Phospholipid

This Sigma-Aldrich article continues to detail new methodology for the analysis of Vitamin D metabolites using HybridSPE-Phospholipid technology.

NMR Deuterated Solvent Properties Reference Chart

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

Mixed-Mode SPE Improves Extraction of Pharmaceutical Compounds from Biological Fluids

New Certified Reference Materials for Proteins

CRMs of milk proteins aid accurate testing for infant formula, ensuring compliance and quality control.

New cis/trans FAME Standard for GC Optimization

AOCS and AOAC methods for trans fatty acid composition require highly polar cyanosilicone capillary columns.

Elemental Impurities - Certified Ref. Materials

Control elemental impurities in drug products with analytical methods and materials to ensure patient safety.

Solid Phase Extraction for Aflatoxin Analysis

Supel Tox AflaZea SPE improves analyte recovery with less sample volume, while HPLC confirms effective elimination of interferences.

Workflow for Pesticide Analysis in Cannabis

Complete workflow for cannabis flower pesticide testing using LC-MS/MS and GC-MS/MS ensures product safety.

Radiello Sampler: Monitoring 1,3-Butadiene & Isoprene

Microbial test method development: Laboratory develops compliant methods for antimicrobial products, ensuring regulatory compliance and quality.

HPLC Separation: Ginsenosides from American Ginseng

Optimize HPLC method for ginsenoside separation using a mixture, applying it to American Ginseng root, with conditions and chromatograms shown.

Isotopically Labeled Steroid Standards

Anabolic steroid testing remains crucial in competitive sports to maintain fairness.

Drinking Water Testing by Ion Chromatography using Ultrapure Water

This study reviews the suitability of ultrapure water for the IC analysis of drinking water. Inorganic ions and disinfectant by-products (DBPs) were assessed.

SPME in the Analysis of Illicit Drugs

SPME is used in the analysis of amphetamine compounds by doing pre-extraction derivatization, and is also used in general determinations of other drugs of abuse.

Ultrapure Water for Metal Analysis in Regulated Food & Beverage Labs

View the suitability of ultrapure water from a Milli-Q system for the multi-elemental analysis (ICP-MS) of toxic metals in foods and drinking water.

Melamine Analysis via GC-MS

Sigma-Aldrich presents an article about the analysis of melamine and related compounds in dog food with the use of more economical gas chromatography-mass spectrometry (GC-MS) instrumentation.

Hopane Reference Standards for use as Petrochemical Biomarkers in Oil Field Remediation and Spill Analysis

We provide high-quality, relevant hopane reference standards to be used as biomarkers for petrochemical oil field remediation and spill analysis.

Reference Standards for Analyzing Polyphenol Catechins

High-Performance Quantitative H-1 NMR

The signal ratio of two different protons can be measured with tremendous precision, which enables the generation of certified reference materials for use as qNMR standards.

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