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Showing 1-30 of 148 results for "L9026" within Papers
S A Summers et al.
Clinical and experimental immunology, 176(3), 341-350 (2014-02-18)
Interleukin (IL)-17A is increased both in serum and in kidney biopsies from patients with lupus nephritis, but direct evidence of pathogenicity is less well established. Administration of pristane to genetically intact mice results in the production of autoantibodies and proliferative
Mingzhu Xu et al.
Cellular reprogramming, 21(3), 129-140 (2019-05-16)
The present study was designed to investigate the comprehensive function of maternal factors of primordial germ cell 7 (PGC7) and POU5F1-POU class 5 homeobox 1 (OCT4), as well as the epigenetic modification roles on the mitosis for the extrusion of
Ying Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15818-15826 (2020-06-17)
Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques expand primarily via the accumulation of cholesterol and inflammatory cells. However, recent evidence suggests that a substantial portion
Ming Meng et al.
Immunogenetics, 71(7), 489-499 (2019-07-13)
Epigenetic modifications have been shown to be important for immune cell differentiation by regulating gene transcription. However, the role and mechanism of histone methylation in the development and differentiation of iNKT cells in rheumatoid arthritis (RA) mice have yet to
Tie-Bo Zeng et al.
FEBS letters, 588(24), 4665-4671 (2014-12-03)
The mouse delta-like homolog 1 and type III iodothyronine deiodinase (Dlk1-Dio3) imprinted domain contains three known paternally methylated differentially methylated regions (DMRs): intergenic DMR (IG-DMR), maternally expressed 3-DMR (Gtl2-DMR), and Dlk1-DMR. Here, we report the first maternally methylated DMR, CpG
Aysha B Khalid et al.
Bone, 144, 115819-115819 (2020-12-19)
GATA4 is a transcription factor that regulates osteoblast differentiation. However, GATA4 is expressed at a higher level in mesenchymal stem cells (MSCs) than in osteoblasts. Therefore, the role of GATA4 in limb bud mesenchyme differentiation was investigated in mice by
Jinbao Wei et al.
Frontiers in cell and developmental biology, 8, 564485-564485 (2020-11-03)
The neonatal or infant period is a critical stage for the development of brain neuroplasticity. Early life stresses in the neonatal period, including neonatal maternal separation (NMS), have adverse effects on an increased risk of psychiatric disorders in juveniles and
Minakshi Gandhi et al.
Nature communications, 11(1), 3214-3214 (2020-06-27)
Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellular carcinoma. Its depletion invokes a proliferation defect, triggers senescence and inhibits colony formation in liver, but also breast and lung cancer cells.
Tohru Fujiwara et al.
Biochemical and biophysical research communications, 485(2), 380-387 (2017-02-22)
The transcription factor GATA-1-interacting protein Friend of GATA-1 (FOG1) is essential for proper transcriptional activation and repression of GATA-1 target genes; yet, the mechanisms by which FOG1 exerts its activating and repressing functions remain unknown. Forced FOG1 expression in human
Ganglong Yang et al.
Journal of proteome research, 14(2), 639-653 (2014-12-24)
Diagnosis of bladder cancer, one of the most common types of human cancer, at an early (nonmuscle-invasive) stage is the best way to reduce the mortality rate. Tumor malignancy in general is closely associated with alterations of glycan expression. Glycosylation
Aya Misawa et al.
Calcified tissue international, 103(4), 422-430 (2018-05-31)
HOTAIR is a lncRNA that plays critical role in gene regulation and chromatin dynamics through epigenetic mechanisms. In this work we studied the physiological role of HOTAIR during the process of mineralization using osteoblastic osteosarcoma cells focusing in ALPL (Tissue
Joohyun Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2269-2274 (2015-01-22)
Prolonged exposure to winter cold enables flowering in many plant species through a process called vernalization. In Arabidopsis, vernalization results from the epigenetic silencing of the floral repressor flowering locus C (FLC) via a Polycomb Repressive Complex 2 (PRC2)-mediated increase
Shuang Liu et al.
Oncotarget, 8(19), 31901-31914 (2017-04-14)
Lysine-specific demethylase 1 (LSD1) has been recognized as a potential therapeutic target for acute myeloid leukemia (AML). Herein, we identified a novel LSD1 inhibitor, JL1037, via Computer Aided Drug Design technology. JL1037 is a potent, selective and reversible LSD1 inhibitor
H Fan et al.
Oncogene, 35(6), 715-726 (2015-04-22)
Chronic hepatitis B virus (HBV) infection is a major risk factor for developing hepatocellular carcinoma (HCC), and HBV X protein (HBx) acts as cofactor in hepatocarcinogenesis. In liver tumors from animals modeling HBx- and HBV-mediated hepatocarcinogenesis, downregulation of chromatin regulating
Shulin Deng et al.
Plant & cell physiology, 56(8), 1667-1678 (2015-06-17)
Transcriptional gene silencing (TGS) is often associated with promoter methylation in both animals and plants. However, the function of DNA methylation in the intragenic region remains unclear. Here, we confirmed that promoter methylation of FLOWERING LOCUS T (FT) led to
Yu Zhang et al.
Biology of reproduction, 98(3), 286-298 (2018-01-27)
In 2011, DEHP (plasticizer) was reported to illegally be added in food and beverage products in Taiwan, which caused great concerns about food safety worldwide. DHEP has multiple toxic effects to human and animals such as endocrine disruption, cardiotoxicity, reproductive
Hao Zhang et al.
Cancer research, 75(11), 2363-2374 (2015-04-10)
Elucidating mechanisms of hepatitis B virus (HBV)-mediated hepatocarcinogenesis is needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is replicating exhibit increased expression of Plk1 kinase and reduced levels of two transcription repression factors
Carlos Diaz-Salazar et al.
The Journal of experimental medicine, 217(4) (2020-02-12)
Natural killer (NK) cells are innate lymphocytes that exhibit adaptive features, such as clonal expansion and memory, during viral infection. Although activating receptor engagement and proinflammatory cytokines are required to drive NK cell clonal expansion, additional stimulatory signals controlling their
Xi Jin et al.
Science advances, 5(3), eaat9820-eaat9820 (2019-03-12)
Human endogenous retroviruses (HERVs) play pivotal roles in the development of breast cancer. However, the detailed mechanisms of noncoding HERVs remain elusive. Here, our genome-wide transcriptome analysis of HERVs revealed that a primate long noncoding RNA, which we dubbed TROJAN
Susu M Zughaier et al.
Pathogens (Basel, Switzerland), 9(2) (2020-02-23)
Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. Neisseria gonorrhoeae is a strict human pathogen that causes the sexually transmitted infection termed gonorrhea. Here, we report that this pathogen
Ahmed Z Balboula et al.
Biology of reproduction, 92(4), 105-105 (2015-03-20)
During meiosis I (MI) in oocytes, the maturation-associated decrease of histone acetylation is critical for normal meiotic progression and accurate chromosome segregation. RBBP4 is a component of several different histone deacetylase containing chromatin-remodeling complexes, but RBBP4's role in regulating MI
Jeong-Hwan Yoon et al.
Nature communications, 6, 7600-7600 (2015-07-22)
Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (TH17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3
Miao Guo et al.
Animal reproduction science, 214, 106287-106287 (2020-02-24)
Estrogen receptor alpha (ERα) is a ligand-activated transcription factor that regulates cellular responses to estrogens and transcription processes of target genes. In this study, changes in DNA methylation and histone modifications in the promoter region and Exon 1 of the
Grace R Williams et al.
Methods (San Diego, Calif.), 92, 36-50 (2015-07-15)
The type 1 parathyroid hormone receptor (PTH1R) is a key regulator of calcium homeostasis and bone turnover. Here, we employed SILAC-based quantitative mass spectrometry and bioinformatic pathways analysis to examine global changes in protein phosphorylation following short-term stimulation of endogenously
Bhavna Padmanabhan et al.
Infection and immunity, 88(3) (2019-12-11)
Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing vacuole (CCV). To establish this unique niche, C. burnetii requires the Dot/Icm type IV secretion system (T4SS) to translocate a cohort of effector proteins into the
Shangrong Wu et al.
Mechanisms of ageing and development, 171, 1-6 (2018-02-06)
The osteogenic capacities of bone marrow-derived stromal cells (BMSCs) diminish during replicative senescence, and these changes affect the success of therapeutic application of BMSCs. In this study, we sought to explore the molecular mechanisms underlying the osteogenic differentiation capacities that
Xue Zhang et al.
Frontiers in cell and developmental biology, 8, 582715-582715 (2020-11-03)
Microcystin-leucine arginine (MC-LR) is the most toxic cyanotoxin found in water bodies. Microcystins are produced as secondary products of cyanobacteria metabolism. They have a stable structure, and can bioaccumulate in living organisms. Humans and livestock who drink fresh water containing
Kathy-Ann Secker et al.
Cancers, 12(5) (2020-05-28)
Epigenetic dysregulation plays a pivotal role in mixed-lineage leukemia (MLL) pathogenesis, therefore serving as a suitable therapeutic target. S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in
Yicun Wang et al.
Inflammation, 40(2), 414-421 (2016-12-29)
Immune suppression plays critical roles in the development of chronic osteomyelitis, and the mechanisms underlying the development of immune suppression in chronic osteomyelitis have attracted much attention. LAG-3 is an important suppressor of T cell activation, but the role of
Michael J Law et al.
G3 (Bethesda, Md.), 7(3), 1001-1010 (2017-02-02)
In the budding yeast
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