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Jan Petersen et al.
Nature structural & molecular biology, 27(1), 49-61 (2019-12-25)
The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear. Here
One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions.
Martelli, Paolo, et al.
Veterinary Microbiology (2010)
Nike Julia Kräutler et al.
Cell reports, 30(4), 997-1012 (2020-01-30)
Control of established chronic lymphocytic choriomeningitis virus (LCMV) infection requires the production of neutralizing antibodies, but it remains unknown how the ensemble of antibodies evolves during ongoing infection. Here, we analyze the evolution of antibody responses during acute or chronic
Mariusz Skwarczynski et al.
Science advances, 6(5), eaax2285-eaax2285 (2020-02-18)
To be optimally effective, peptide-based vaccines need to be administered with adjuvants. Many currently available adjuvants are toxic, not biodegradable; they invariably invoke adverse reactions, including allergic responses and excessive inflammation. A nontoxic, biodegradable, biocompatible, self-adjuvanting vaccine delivery system is
Fang Chen et al.
Gastroenterology, 158(4), 1058-1071 (2019-12-07)
We investigated antibody responses to hepatitis C virus (HCV) antigens E1 and E2 and the relevance of animal models for vaccine development. We compared antibody responses to vaccination with recombinant E1E2 complex in healthy volunteers, non-human primates (NHPs), and mice.
Simone Joas et al.
Cell reports, 30(7), 2261-2274 (2020-02-23)
The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activation and pathogenicity remains speculative.
Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms.
Afonso, Georgia, et al.
Journal of Immunological Methods, 359, 28-36 (2010)
Sean H Kelly et al.
Biomaterials, 241, 119903-119903 (2020-03-07)
Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in sublingual vaccines owing to the challenges
Evaluation of the immune response induced by intradermal vaccination by using a needle-less system in comparison with the intramuscular route in conventional pigs.
Ferrari, L, et al.
Research in Veterinary Science (2010)
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