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Ondřej Kučera et al.
Nature communications, 12(1), 4595-4595 (2021-07-30)
Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step during cell division. Mechanical forces driving the constriction are attributed to myosin motor proteins, which slide actin filaments along each other. However, in multiple organisms
Muskan Kanungo et al.
Polymers, 13(19) (2021-10-14)
A major challenge in tissue engineering is the formation of vasculature in tissue and organs. Recent studies have shown that positively charged microspheres promote vascularization, while also supporting the controlled release of bioactive molecules. This study investigated the development of
Yu Cheng et al.
Animals : an open access journal from MDPI, 11(6) (2021-06-03)
The aim of the present study was to investigate the spontaneous motility of spermatozoa and to optimize sperm collection, short-term sperm storage, and fertilization in zebrafish Danio rerio. The movement of spermatozoon in water was propagated along the flagellum at
Pablo Rougerie et al.
Scientific reports, 10(1), 14784-14784 (2020-09-10)
How biophysical cues can control tissue morphogenesis is a central question in biology and for the development of efficient tissue engineering strategies. Recent data suggest that specific topographies such as grooves and ridges can trigger anisotropic tissue growth. However, the
Ying Lian et al.
Methods and applications in fluorescence, 6(3), 034002-034002 (2018-03-24)
Cyanine dyes are widely used in biological labeling and imaging because of their narrow near infrared emission, good brightness and high flexibility in functionalization, which not only enables multiplex analysis and multi-color imaging, but also greatly reduces autofluorescence from biological
Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If
Marta Urbanska et al.
Small (Weinheim an der Bergstrasse, Germany), 17(18), e2007388-e2007388 (2021-03-25)
Cytoskeletal motors transform chemical energy into mechanical work to drive essential cellular functions. Optical trapping experiments have provided crucial insights into the operation of these molecular machines under load. However, the throughput of such force spectroscopy experiments is typically limited
Albert Barba et al.
ACS applied materials & interfaces, 9(48), 41722-41736 (2017-11-09)
Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still unclear, microporosity and specific surface area (SSA) have
Miaomiao Xin et al.
Fish physiology and biochemistry, 44(6), 1527-1533 (2018-07-20)
The loss of sperm quality in sterlet (Acipenser ruthenus) due to freeze-thaw process in cryopreservation was investigated in the present study. Two antifreeze proteins (AFPI or AFPIII) were used at different concentrations of 0.1, 1, 10, and 100 μg/mL. We compared
Isabel N Tromp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(9), 1955-1964 (2020-11-23)
It has been suggested that curvature progression in adolescent idiopathic scoliosis occurs through irreversible changes in the intervertebral discs. Strains of mice have been identified who differ in their disc wedging response upon extended asymmetrical compression. Annulus fibrosus (AF) tissue
Kai-Chiang Yang et al.
Materials science & engineering. C, Materials for biological applications, 110, 110733-110733 (2020-03-25)
Scaffold geometry is known a biophysical spatial cue to modulate stem cell fate. However, the effect of regulating topography on the chondrogenic differentiation of adipose-derived stem cells (ADSCs) is not fully understood. In this study, a spatial-controlled scaffold was prepared
Hanna Tay et al.
Cells, 10(1) (2020-12-31)
Macrophages play an important but poorly understood role in angiogenesis. To investigate their role in vessel formation, relevant in vivo models are crucial. Although the chick chorioallantoic membrane (CAM) model has been frequently used as an angiogenesis assay, limited data
Advait Shetty et al.
ACS omega, 5(15), 8982-8991 (2020-04-28)
Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an advanced and metastatic stage. Gemcitabine (GEM) is
Kyung Min Lim et al.
Antioxidants (Basel, Switzerland), 10(8) (2021-08-28)
Extracellular vesicles (EVs) are paracrine factors that mediate stem cell therapeutics. We aimed at evaluating the possible therapeutic and esthetic applications of EVs prepared from the waste human facial tissue-derived orbicularis oculi muscle stem cells (OOM-SCs). OOM-SCs were isolated from
Juanjuan Dai et al.
JCI insight, 6(2) (2021-01-26)
Severe acute pancreatitis (AP) is a life-threatening disease with up to 30% mortality. Therefore, prevention of AP aggravation and promotion of pancreatic regeneration are critical during the course and treatment of AP. Hypertriglyceridemia (HTG) is an established aggravating factor for
Harpinder Saini et al.
Biomaterials, 247, 119975-119975 (2020-04-12)
The tumor microenvironment has been demonstrated to play a crucial role in modulating cancer progression. Amongst various cell types within the tumor microenvironment, cancer associated fibroblasts (CAFs) are in abundance, serving to modulate the biophysical properties of the stromal matrix
Susruta Samanta et al.
The journal of physical chemistry. B, 117(11), 3250-3257 (2013-02-28)
Curcumin, a naturally occurring drug molecule, has been extensively investigated for its various potential usages in medicine. Its water insolubility and high metabolism rate require the use of drug delivery systems to make it effective in the human body. Among
Federico Ceriani et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7194-E7201 (2016-11-04)
Spatially and temporally coordinated variations of the cytosolic free calcium concentration ([Ca2+]c) play a crucial role in a variety of tissues. In the developing sensory epithelium of the mammalian cochlea, elevation of extracellular adenosine trisphosphate concentration ([ATP]e) triggers [Ca2+]c oscillations
Petros Andrikopoulos et al.
Cellular signalling, 37, 12-30 (2017-05-26)
It has been previously demonstrated that the bi-directional transporter Na
Xiao-Dong Li et al.
Cardiovascular research, 116(3), 708-720 (2019-06-27)
Adventitial vasa vasorum provides oxygen and nourishment to the vascular wall, but whether it regulates vascular disease remains unclear. We have previously shown that an increased expression of VEGF (vascular endothelial growth factor) is associated with macrophage infiltration. This study
Karthik Damodaran et al.
Molecular biology of the cell, 29(25), 3039-3051 (2018-09-27)
Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical and biochemical signals in their local microenvironment to regulate genomic programs via chromatin remodelling. While in connective tissues fibroblasts experience tensile and compressive forces (CFs), the role of compressive
Xiaoyan Dai et al.
Circulation research, 119(10), 1089-1100 (2016-10-30)
Elevated levels of CHOP (C/EBP homologous protein), a member of the C/EBP transcription factor family, in advanced atherosclerotic plaques is reported to be associated with atherosclerotic plaque rupture in humans. However, the molecular mechanism by which CHOP accumulation occurs is
Alexander S Zhovmer et al.
Molecular biology of the cell, 30(16), 1961-1973 (2019-07-19)
Contact guidance refers to the ability of cells to sense the geometrical features of the microenvironment and respond by changing their shape and adopting the appropriate orientation. Inhibition and ablation of nonmuscle myosin 2 (NM2) paralogues have demonstrated their importance
A Lee et al.
Science (New York, N.Y.), 365(6452), 482-487 (2019-08-03)
Collagen is the primary component of the extracellular matrix in the human body. It has proved challenging to fabricate collagen scaffolds capable of replicating the structure and function of tissues and organs. We present a method to 3D-bioprint collagen using
Micromechanics of the Vertebrate Meiotic Spindle Examined by Stretching along the Pole-to-Pole Axis
Takagi J, et al.
Biophysical Journal, 106(3), 735-740 (2014)
Marcilio S S Cunha-Filho et al.
TheScientificWorldJournal, 2012, 126723-126723 (2012-05-26)
This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). Pluronic dispersions prepared at various concentrations in the absence and the
Shravanthi Rajasekar et al.
Advanced materials (Deerfield Beach, Fla.), 32(46), e2002974-e2002974 (2020-10-02)
Despite the complexity and structural sophistication that 3D organoid models provide, their lack of vascularization and perfusion limit the capability of these models to recapitulate organ physiology effectively. A microfluidic platform named IFlowPlate is engineered, which can be used to
Zhenyuan Xu et al.
Journal of tissue engineering and regenerative medicine, 14(2), 229-242 (2019-11-09)
Peripheral nerve injuries require a complex set of signals from cells, macrophages, and the extracellular matrix (ECM) to induce regeneration across injury sites and achieve functional recovery. Schwann cells (SCs), the major glial cell in the peripheral nervous system (PNS)
Luciano Vidal et al.
Scientific reports, 10(1), 7068-7068 (2020-04-29)
Although autografts are considered to be the gold standard treatment for reconstruction of large bone defects resulting from trauma or diseases, donor site morbidity and limited availability restrict their use. Successful bone repair also depends on sufficient vascularization and to
Veronica Zorzi et al.
Frontiers in molecular neuroscience, 10, 379-379 (2017-12-14)
Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory function is unclear due
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