Search Within
T4069
Applied Filters:
Keyword:'T4069'
Showing 1-30 of 2333 results for "T4069" within Papers
Ruo-Lan Li et al.
Oxidative medicine and cellular longevity, 2020, 3481758-3481758 (2020-07-23)
Zanthoxylum bungeanum pericarp is a commonly used herbal medicine in China with effects of anti-inflammatory and analgesic, improving learning and memory ability, while hydroxy-α-sanshool (HAS) is the most important active ingredient of Z. bungeanum pericarps. The purpose of this study
Chenxi Yan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 68, 104933-104933 (2020-07-12)
Indoor pollution with cooking oil fumes (COF) as one of the main components is closely related to ocular surface disorders. However, as the most abundant aldehyde in COF, the toxicity of trans, trans-2,4-decadienal (tt-DDE) on human cornea has not been
Min-Yan Yang et al.
Journal of pharmacological sciences, 145(1), 105-114 (2020-12-29)
Brain microvascular endothelial cells (BMECs) dysfunction is related to the pathogenesis of neurovascular complication of diabetes mellitus that adversely lead to various CNS disorders. Mitoquinone (MitoQ) is a mitochondria targeted antioxidant that exerts multiple protective effects in many oxidative damage-related
Zhendong Zhao et al.
Molecules (Basel, Switzerland), 23(6) (2018-06-09)
Curcumin is acknowledged for its antioxidant, anti-inflammatory, anti-cancer, and wound-healing properties. However, the biological activity and the molecular mechanisms of T59, which is a new derivative of curcumin, are not fully understood. The present study was aimed to determine the
Jianxu Zhang et al.
Colloids and surfaces. B, Biointerfaces, 129, 54-62 (2015-04-02)
In this paper, N-isopropylacrylamide-modified polyethylenimine (PEN) was constructed through Michael addition and employed as a carrier to achieve the p53 gene delivery, using HeLa (p53wt) and PC-3 cells (p53null) as models. After PEN-mediated p53 transfection, expression level of p53 in
Zixu Wang et al.
Food chemistry, 344, 128566-128566 (2020-11-17)
Three scallop protein hydrolysates (SPH) were obtained by enzymatic hydrolysis of scallop meal by Pepsin, Dispase and Alcalase, respectively. The antioxidant activities of the SPHs were characterized for their free radical scavenging activities through 1,1-diphenyl-2-picrylhydrazyl (DPPH)/hydroxyl/2,2' azino-bis-3-(ethylbenzthiazoline-6-sulphonic acid) (ABTS) assays
Na Xu et al.
International journal of molecular sciences, 19(12) (2018-12-16)
Morchella conica Pers. (M. conica) has been used both as a medical and edible mushroom and possesses antimicrobial properties and antioxidant activities. However, the antioxidant properties of polysaccharides purified from M. conica have not been studied. The aim of this
Zhen Dong et al.
British journal of cancer, 116(12), 1572-1584 (2017-05-12)
Backgroud:Glioblastoma is a kind of highly malignant and aggressive tumours in the central nervous system. Previously, we found that neurotensin (NTS) and its high-affinity receptor 1 (NTSR1) had essential roles in cell proliferation and invasiveness of glioblastoma. Unexpectedly, cell death
Chunchun Wang et al.
Journal of agricultural and food chemistry, 67(5), 1409-1417 (2019-01-03)
The study evaluated the effects of butyric acid, in the form of tributyrin on the oxidative stress, inflammation, and mitochondrial function in diquat-challenged pigs. Twenty-four weaned pigs were allocated to four treatments in a 2 × 2 factorial arrangement with
Jiping Gao et al.
Biological trace element research, 199(2), 682-692 (2020-07-03)
Fluoride is widely distributed in nature, and at high concentrations, it targets the kidney and especially proximal tubule epithelial cells. Selenium is a typical trace element beneficial to humans, and the role of selenium in the prevention and treatment of
Shuangyue Li et al.
Industrial health, 55(2), 108-118 (2016-11-15)
2,5-hexanedione (HD) is the ultimate neurotoxic metabolite of hexane, causing the progression of nerve diseases in human. It was reported that HD induced apoptosis and oxidative stress. Taurine has been shown to be a potent antioxidant. In the present study
Tom70 protects against diabetic cardiomyopathy through its antioxidant and antiapoptotic properties.
Peijian Wang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 43(10), 1047-1056 (2020-07-30)
Mitochondrial dysfunction plays a critical role in the pathogenesis of diabetic cardiomyopathy. Translocase of mitochondrial outer membrane 70 (Tom70) primarily facilitates the import of mitochondrial preproteins that may be involved in the regulation of oxidative stress and mitochondrial function. This
Lin Li et al.
Frontiers in pharmacology, 11, 815-815 (2020-06-26)
Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of cardiovascular disease and in the control of cardiac toxicity induced by doxorubicin (DOX) treatment. However, its
Yujie Zhong et al.
Toxicon : official journal of the International Society on Toxinology, 137, 106-113 (2017-07-25)
Mycotoxins like patulin (PAT) are among the most significant food contaminant with regard to public health. This study aimed to evaluate the protective effect of apigenin (API), one of the most bioactive flavonoids in plant-derived food, on PAT-induced apoptosis in
Shengchuan Cao et al.
Biochemical and biophysical research communications, 522(2), 518-524 (2019-12-01)
Acute pancreatitis (AP) is one of the leading causes of hospital admission for gastrointestinal disorders. Although lipid peroxides are produced in AP, it is unknown if targeting lipid peroxides prevents AP. This study aimed to investigate the role of mitochondrial
Mustafa Nazıroğlu et al.
PloS one, 12(6), e0179950-e0179950 (2017-06-24)
There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has anticancer activity. However, capsaicin cannot be given systemically in large doses, because of its induction of acute
Haobo Han et al.
Biomaterials science, 5(11), 2268-2275 (2017-10-05)
The nucleobase analogue 2-amino-6-chloropurine was modified on the surface of polyamidoamine (PAMAM) to construct a derivative AP-PAMAM, and then it was used as a gene carrier for miR-23b delivery to achieve the anti-tumor effects. The carrier AP-PAMAM could condense miR-23b
He Liu et al.
Cell death and differentiation, 26(6), 1048-1061 (2018-08-30)
Stem cells are generally believed to contain a small number of mitochondria, thus accounting for their glycolytic phenotype. We demonstrate here, however, that despite an indispensable glucose dependency, human dermal stem cells (hDSCs) contain very numerous mitochondria. Interestingly, these stem
Qiyi Zhao et al.
Cell, 183(1), 76-93 (2020-09-16)
Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system. By circular RNA (circRNA) expression profile analysis of liver
Xiaochen Huang et al.
Food & function, 10(2), 1049-1061 (2019-02-02)
The present study was designed to explore the neuroprotective effects of docosahexaenoic acid (DHA) and/or vitamin E (VE) in vitro. The PC12 cells were pretreated with DHA and/or VE for 4 h, followed by 50 μmol L-1 Aβ25-35 treatments for
Hye Young Kim et al.
Cancer letters, 355(1), 61-69 (2014-09-15)
Previous studies have revealed that HBx expression has anti-apoptotic effects, resulting in increased drug resistance in HCC cells. Thus, we examined if sorafenib efficiently induces apoptosis in HBx-overexpressing HCC cells. Noticeably, sorafenib efficiently induced apoptosis, even in HBx-expressing HepG2 cells
Zengenni Liang et al.
International journal of molecular sciences, 20(3) (2019-01-27)
Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) Karst, a traditional Chinese medicine, is a biologically active substance reported to possess anti-oxidative, anti-apoptotic, and neurological protection. However, it is unknown whether GLP have any protective effect against
Md Mohibbullah et al.
Journal of medicinal food, 18(9), 960-971 (2015-06-25)
Age-related neurological disorders are of growing concern among the elderly, and natural products with neuroprotective properties have been attracting increasing attention as candidates for the prevention or treatment of neurological disorders induced by oxidative stress. In an effort to explore
Jun Ho Yang et al.
Cells, 8(5) (2019-05-17)
Lipid emulsion (LE) therapy has been used to reduce overdose of bupivacaine (BPV)-induced cardiotoxicity. The TWIK-related potassium channel-1 (TREK-1) is inhibited by BPV and activated by polyunsaturated fatty acids, which are the main component in LE. These pharmacological properties inspired
Zahra Safaei et al.
Journal of cellular physiology, 235(9), 6113-6126 (2020-02-13)
Polycystic ovarian syndrome (PCOS) is a disorder characterized by oligomenorrhea, anovulation, and hyperandrogenism. Altered mitochondrial biogenesis can result in hyperandrogenism. The goal of this study was to examine the effect of vitamin D3 on mitochondrial biogenesis of the granulosa cells
Luisa Zupin et al.
Journal of biophotonics, 12(10), e201900043-e201900043 (2019-06-21)
Laser therapy, also known as Photobiomodulation (PBM) is indicated to reduce pain associated with different pathologies and applied using protocols that vary in wavelength, irradiance and fluence. Its mechanisms of action are still unclear and possibly able to directly impact
Wonhyoung Park et al.
Phytotherapy research : PTR, 34(9), 2275-2286 (2020-03-20)
Endometriosis is a reproductive disorder characterized by the dislocation of endometrial tissues. Approximately 5-20% of women at their reproductive age are diagnosed with endometriosis, which causes chronic pain and infertility. Here, we demonstrated that the bioactive flavonoid, 5,7-dimethoxyflavone (DMF), exhibited
Tommaso Di Palma et al.
Zygote (Cambridge, England), 28(4), 300-307 (2020-04-15)
Information on donkey sperm bioenergetics, kinetics and oxidative status is scarce even though crucial for development of reproductive technologies and germplasm conservation. For these reasons, it is interesting to monitor sperm kinetics, bioenergetics, and oxidative status during sperm storage at
Adnan Khan et al.
Animals : an open access journal from MDPI, 10(6) (2020-06-25)
Heat stress in dairy cattle is recognized to compromise fertility by altering the functions of ovarian follicle-enclosed cells, e.g., oocyte and granulosa cells (GCs). Catalase is an antioxidant enzyme that plays a significant role in cellular protection against oxidative damage
Dipanwita Das Mukherjee et al.
Biochimica et biophysica acta. Molecular cell research, 1867(10), 118762-118762 (2020-06-06)
Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries
Page 1 of 78