This product is packaged in mass, and the exact volume is not measured. However, the density is 0.813 g/mL at 25 degrees Celsius, so a 2.5 gram bottle should nominally contain approximately 3.08 mL of solution, while a 10 gram bottle should nominally contain approximately 12.32 mL of solution.
412449
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution
10 wt. % in methanol
Synonym(s):
Starburst Generation 4
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About This Item
Linear Formula:
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
CAS Number:
Molecular Weight:
14214.17
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
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Product Name
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution, 10 wt. % in methanol
description
amino surface groups
form
solution
mol wt
generation 4.0
feature
core type ethylenediamine core (2-carbon core)
concentration
10 wt. % in methanol
no. Surface Groups
64
refractive index
n20/D 1.348
bp
64.7 °C
density
0.813 g/mL at 25 °C
storage temp.
2-8°C
Quality Level
Related Categories
1 of 4
This Item | 412422 | 412430 | 412384 |
|---|---|---|---|
| refractive index n20/D 1.348 | refractive index n20/D 1.367 | refractive index n20/D 1.346 | refractive index n20/D 1.362 |
| form solution | form liquid | form solution | form liquid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| density 0.813 g/mL at 25 °C | density 0.863 g/mL at 25 °C | density 0.81 g/mL at 25 °C | density 0.82 g/mL at 25 °C |
| description amino surface groups | description amino surface groups | description sodium carboxylate surface groups | description amino surface groups |
| mol wt generation 4.0 | mol wt generation 3.0 | mol wt generation 3.5 | mol wt generation 1.0 |
Application
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is used as a compacting agent to bring in the conformational changes in the DNA molecule.[1] It can be attached on the cellulose substrate that acts as a biofunctional surface for potential applications in immonoassays.[2] It is used in MRI contrast agents[3] and in the condensation formation of silica nanospheres.[4]
General description
PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is a poly(amidoamine) that is categorized as a class of dendritic polymers which can be prepared by a two-step interactive reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular “branched upon branched” pattern. It is majorly used as a high capacity chelating agent.[5][6]
Legal Information
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
Physical form
Contains 64 surface primary amino groups
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves
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Felipe Vidal et al.
Molecular pharmaceutics, 13(10), 3395-3403 (2016-08-25)
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with
Rolando Alberto Rodríguez-Fonseca et al.
Colloids and surfaces. B, Biointerfaces, 177, 77-93 (2019-02-04)
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
Ainalem M, et al.
PLoS ONE, 9(3), e92692-e92692 (2014)
Marta Walczynska et al.
Toxicology mechanisms and methods, 28(6), 432-439 (2018-04-03)
Nematode Caenorhabditis elegans (C. elegans) was used to investigate the impact of silver nanoparticles (SNP), multiwalled carbon nanotubes (MWCNT), and polyamidoamine dendrimers (PAMAM) used in concentration of 1010 particle/mL. Population-based observations and gene expression analysis were employed in this study.
Dendritic chelating agents. 1. Cu (II) binding to ethylene diamine core poly (amidoamine) dendrimers in aqueous solutions
Diallo MS, et al.
Langmuir, 20(7), 2640-2651 (2004)
Articles
Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.
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Hello, What is the total volume of solution in the bottle containing PAMAM dendrimer, ethylenediamine core, generation 4.0 solution size of 2.5 G?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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