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Aminopeptidase M, Porcine Kidney

Name: Aminopeptidase M, Porcine Kidney
Brand: MM

Synonym(s):

Aminopeptidase M, Porcine Kidney, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N

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About This Item

CAS Number:

9054-63-1

EC Number:

3.4.11.2 (BRENDA, IUBMB)

UNSPSC Code:

12352202

NACRES:

NA.54

MDL number:

MFCD00131501

Biological source:

Porcine kidney

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Properties

biological source

Porcine kidney

Quality Segment

100

form

suspension (crystalline)

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

physiological buffer: soluble, water: soluble

foreign activity

Oxidases ≤3%

shipped in

ambient

storage temp.

2-8°C

Description

General description

Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.

Application

Aminopeptidase M, porcine kidney has been used:

to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
for the proteolysis of isolevuglandins (IsoLGs) proteins

Biochem/physiol Actions

Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.

Other Notes

One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.

Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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This Item	L5006	L6007	A8200
Sigma-Aldrich 164598 Aminopeptidase M, Porcine Kidney	Sigma-Aldrich L5006 Leucine Aminopeptidase, microsomal from porcine kidney	Sigma-Aldrich L6007 Leucine Aminopeptidase, microsomal from porcine kidney	Sigma-Aldrich A8200 Aminopeptidase from Aeromonas proteolytica
description -	description Type IV-S, ammonium sulfate suspension, 10-40 units/mg protein (Bradford)	description Type VI-S, lyophilized powder, ≥12 units/mg protein (biuret)	description lyophilized powder, 50-150 units/mg protein
biological source Porcine kidney	biological source -	biological source Porcine kidney	biological source -
form suspension (crystalline)	form ammonium sulfate suspension	form lyophilized powder	form lyophilized powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility physiological buffer: soluble, water: soluble	solubility -	solubility -	solubility H₂O: soluble 0.9-1.1 mg/mL, clear, colorless
storage condition OK to freeze	storage condition -	storage condition -	storage condition -
shipped in ambient	shipped in -	shipped in -	shipped in -

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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