164610

p-Aminophenylmercuric Acetate

≥90% (HPLC), MMP activator, solid

• Synonym(s): p-Aminophenylmercuric Acetate, APMA
• Empirical Formula (Hill Notation): C₈H₉HgNO₂
• CAS Number: 6283-24-5
• Molecular Weight: 351.75
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00007820
• Assay: ≥90% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Product Name: p-Aminophenylmercuric Acetate, An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.
• Quality Segment: 100
• description: RTECS - OV5550000
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: yellow
• solubility: 0.1 M NaOH: 10 mg/mL, DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [Hg+]c1ccc(cc1)N.[O-]C(=O)C
• InChI: 1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1
• InChI key: RXSUFCOOZSGWSW-UHFFFAOYSA-M

Description

General description

An organomercurial agent used for the activation of latent matrix metalloproteinases (MMPs) in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activation of latent MMPs in vitro

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Chen, J.-M., et al. 1991. J. Biol. Chem. 266, 5113.
Marcy, A.I., et al. 1991. Biochemistry30, 6476.
Stricklin, G.P., et al. 1983. Biochemistry22, 61.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Toxicity: Highly Toxic (H)

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Codes: H300 + H310 + H330,H373,H410
• Precautionary Statements: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable