This product is a 100 mM (10 mg/438 µl) solution of 5-Aza-2'-Deoxycytidine in DMSO. Mixing with additional DMSO is not necessary.
189826
5-Aza-2′-Deoxycytidine
≥98% (HPLC), liquid, DNA methyltransferase inhibitor, Calbiochem
Synonym(s):
InSolution 5-Aza-2′-Deoxycytidine, Decitabine
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About This Item
Empirical Formula (Hill Notation):
C8H12N4O4
CAS Number:
Molecular Weight:
228.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Pricing and availability is not currently available.
Product Name
5-Aza-2′-Deoxycytidine, InSolution, ≥98%, DNA methyltransferase inhibitor
Quality Segment
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
ambient
storage temp.
−20°C
SMILES string
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key
XAUDJQYHKZQPEU-UHFFFAOYSA-N
General description
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.
Packaging
Packaged under inert gas
Physical form
A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.
Other Notes
Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
1 of 1
This Item | |||
|---|---|---|---|
| description InSolution, ≥98%, DNA methyltransferase inhibitor | description A cytosine analog that acts as a DNA methyltransferase inhibitor. | description United States Pharmacopeia (USP) Reference Standard | description ≥97% |
| form liquid | form lyophilized | form - | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay ≥97% |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename USP | manufacturer/tradename - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| storage condition desiccated (hygroscopic), OK to freeze, protect from light | storage condition OK to freeze | storage condition - | storage condition - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Muta. 2 - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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