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204885

Complement C3, Human

Complement C3, Human, CAS 80295-41-6, is a native C3 component. Glycoprotein composed of two non-identical disulfide-bonded subunits of 115 kDa (α) and 75 kDa (β).

Synonym(s):

Complement C3, Human

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About This Item

CAS Number:
80295-41-6
UNSPSC Code:
12352202
NACRES:
NA.25
MDL number:
MFCD00130836
Form:
liquid
Assay:
≥85% (SDS-PAGE)
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Quality Segment

assay

≥85% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, C4, functionally active C5, albumin or ceruloplasmin, trace

shipped in

wet ice

storage temp.

−70°C

General description

Native, human C3 complement component. Glycoprotein composed of two non-identical disulfide-bonded subunits with M.W. of 115,000 (α) and 75,000 (β). Present in normal human serum at 1.25 mg/ml. Classical and alternative activation pathways of complement converge at the C3 step. Activation via either pathway can result in assembly of C3-cleaving enzymes (C3 convertases) on target surfaces. Both C3 convertases cleave the C3 α-chain at peptide bond 77, resulting in production of C3a (M.W. 9083) and C3b fragments (M.W. 180,000). Released C3a peptide is one of the three complement anaphylatoxins. The nascent C3b fragment can form a covalent ester bond with target surface. The covalent attachment of C3b to target acceptors is required for continuation of complement activation.

Biochem/physiol Actions

>3,000 C₃H₅0 units/mg; ≥60% of the C3 activity in normal human serum on a mg/mg basis.

Physical form

In PBS.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Lambris, J.D. and Muller-Eberhard, H.J. 1986. Mol. Immunol.23, 1237.
Tack, B.F., et al. 1980. Methods Enzymol. 80, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Complement C3, Human Complement C3, Human, CAS 80295-41-6, is a native C3 component. Glycoprotein composed of two non-identical disulfide-bonded subunits of 115 kDa (α) and 75 kDa (β).

Sigma-Aldrich

204885

Complement C3, Human

Complement C2, Human Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.

Sigma-Aldrich

204882

Complement C2, Human

Complement C1, Human Complement C1, Human Native, is the first component of the classical complement pathway. It is a calcium-dependent complex of C1q, C1r, and C1s subcomponents.

Sigma-Aldrich

204873

Complement C1, Human

Complement C1q, Human Complement C1q, Human, CAS 80295-33-6, is a native C1q complement component composed of 18 polypeptide chains consisting of three nonidentical A, B, C subunits of 29, 26, and 19 kDa, respectively.

Sigma-Aldrich

204876

Complement C1q, Human

description

Complement C3, Human, CAS 80295-41-6, is a native C3 component. Glycoprotein composed of two non-identical disulfide-bonded subunits of 115 kDa (α) and 75 kDa (β).

description

Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.

description

Complement C1, Human Native, is the first component of the classical complement pathway. It is a calcium-dependent complex of C1q, C1r, and C1s subcomponents.

description

Complement C1q, Human, CAS 80295-33-6, is a native C1q complement component composed of 18 polypeptide chains consisting of three nonidentical A, B, C subunits of 29, 26, and 19 kDa, respectively.

assay

≥85% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

-

assay

≥90% (SDS-PAGE)

form

liquid

form

liquid

form

liquid

form

liquid

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

avoid repeated freeze/thaw cycles, OK to freeze

storage condition

avoid repeated freeze/thaw cycles, OK to freeze

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

impurities

IgG, IgA, IgM, C4, functionally active C5, albumin or ceruloplasmin, trace

impurities

C1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace

impurities

-

impurities

IgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin, trace

Storage Class

12 - Non Combustible Liquids

WGK

WGK 2

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