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344096

Sigma-Aldrich

InSolution Fluvastatin, Sodium Salt

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

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Synonym(s):
InSolution Fluvastatin, Sodium Salt, (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
Empirical Formula (Hill Notation):
C24H25FNNaO4
CAS Number:
93957-55-2
Molecular Weight:
433.45
MDL number:
MFCD08063391

Quality Level

100

Assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1

InChI key

ZGGHKIMDNBDHJB-RPQBTBOMSA-M

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This Item
PHR1620SML0038344095-M
InSolution Fluvastatin, Sodium Salt A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

Sigma-Aldrich

344096

InSolution Fluvastatin, Sodium Salt

Fluvastatin sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1620

Fluvastatin sodium

Fluvastatin sodium hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0038

Fluvastatin sodium hydrate

Fluvastatin, Sodium Salt A synthetic HMG-CoA reductase inhibitor (IC₅₀ = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent.

Millipore

344095-M

Fluvastatin, Sodium Salt

form

liquid

form

-

form

powder

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage condition

-

storage condition

desiccated

storage condition

OK to freeze, protect from light

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

-

storage temp.

−70°C

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

−20°C

General description

A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.

Biochem/physiol Actions

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.

Other Notes

Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145.
Ikeda, U., et al. 2000. Hypertension36, 325.
Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630.
Yuan, J., et al. 1991. Atherosclerosis87, 147.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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