Merck
  • 504844
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5.04844

Sigma-Aldrich

7-Chlorokynurenic Acid Sodium Salt

Synonym(s):
7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
Empirical Formula (Hill Notation):
C10H5ClNNaO3
CAS Number:
Molecular Weight:
245.59

Assay

≥99% (HPLC)

Quality Level

form

solid

potency

0.56 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

2-8°C

InChI

1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1

InChI key

IFZYIORLNGNLEI-UHFFFAOYSA-M

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This Item
5.04841N4382407719
assay

≥99% (HPLC)

assay

≥99% (HPLC)

assay

-

assay

≥98% (HPLC)

form

solid

form

solid

form

powder

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

OK to freeze, desiccated

color

white

color

white

color

-

color

white to pale yellow

solubility

water: 100 mM

solubility

water: 10 mM, 1 M NaOH: 100 mM

solubility

-

solubility

water: 100 mg/mL

General description

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

Biochem/physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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