Merck
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D6924

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

average mol wt 9,000-20,000

CAS Number:
MDL number:
NACRES:
NA.21

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

form

powder

optical activity

[α]/D 90 to 105 °, c = 6% (w/v)

mol wt

average mol wt 9,000-20,000

composition

Sulfur Content, 16.0-19.0%

solubility

H2O: 100 mg/mL

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This Item
D4911D600168841
biological source

bacterial (Leuconostoc mesenteroides)

biological source

bacterial (Leuconostoc)

biological source

bacterial (Leuconostoc mesenteroides)

biological source

-

form

powder

form

powder

form

powder

form

powder

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

optical activity

[α]/D 90 to 105 °, c = 6% (w/v)

optical activity

-

optical activity

[α]/D 90 to 105 °, c = 6% (w/v) in water

optical activity

-

mol wt

average mol wt 9,000-20,000

mol wt

6,500-10,000

mol wt

average mol wt >500,000 (dextran starting material)

mol wt

Mr ~20,000

General description

Dextran sulfate sodium is a natural polymer of α-1,6-D-glucopyranose. It is a hydrophilic, biodegradable, and biocompatible polyanionic polymer. This highly branched polysaccharide has 1,6 and 1,4 glycosidic linkages, consisting of 2.3 sulfate groups per glucosyl unit.

Application

Dextran sulfate sodium salt from Leuconostoc spp. has been used:
  • to evaluate the participation of sulfated glycans on the interaction of recombinant human proacrosin/acrosin with zona pellucida (ZP) glycoproteins
  • to inject into the vitreous cavity of embryonic day five chick embryos to assess the eye size and to study its impact on cell proliferation in the retina
  • to test the structural specificity of binding of TNF-stimulated gene 6 (TSG-6) to immobilized hyaluronan (HA)

Biochem/physiol Actions

Dextran sulfate may exhibit anti-coagulant and antiviral properties. It may also help to lower cholesterol levels. It is extensively used as a plasma volume expander and fibrinolytic in the medical field. Dextran sulfate can also be used as a cross-linker for chitosan (CH).

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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