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B9806

Sigma-Aldrich

Heparin−biotin sodium salt

≥97%

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Synonym(s):
Heparin-Biotin Conjugate
MDL number:
UNSPSC Code:
12352201
eCl@ss:
34058011
NACRES:
NA.25

conjugate

biotin conjugate

Quality Level

Assay

≥97%

form

solid

mol wt

~15000 Da

solubility

H2O: soluble 1 mg/mL, clear, colorless

storage temp.

2-8°C

Application

Heparin-biotin is used transfection research for the development of self-assembled terplexes such as polyamidoamine dendrimer and DNA (PAMAM/DNA) heparin-biotin terplexes for targeted gene delivery with improved transfection. The terplexes may be used in immobilizing proteins such as lactoferrin and lysozyme and nucleic acids.

Other Notes

Biotin conjugated to heparin from porcine intestinal mucosa

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
Stefan D Gentile et al.
Frontiers in bioengineering and biotechnology, 8, 792-792 (2020-08-15)
The study of the liver progenitor cell microenvironment has demonstrated the important roles of both biochemical and biomechanical signals in regulating the progenitor cell functions that underlie liver morphogenesis and regeneration. While controllable two-dimensional in vitro culture systems have provided

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