Collagenase from Clostridium histolyticum
has been used in determining the degradation rate of collagen biomaterials.
It may also be used to determine the enzymatic degradation and enzymatic resistance by the liberated L-leucine measurements.
Collagenase from Clostridium histolyticum, or Clostridiopeptidase A, has been used in a study to assess contact dermatitis with clostridiopeptidase A contained in Noruxol ointment. Clostridiopeptidase A has also been used in a study to investigate the early and successful enzymatıc debridement via collagenase application to pinna in a preterm neonate.
The enzyme has been used in the isolation of mast cells from adult mice. This study generated a large number of connective tissue-type mast cells by the culture of murine fetal skin cells.
The product has also been used in the in vitro
biodegradation study of Bombyx mori
silk fibroin fibers and films, by exposing them to the enzyme for varied time periods.