Merck
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H7640

Sigma-Aldrich

Heparan sulfate sodium salt from bovine kidney

All Photos(3)
Synonym(s):
Heparitin sulfate sodium salt
CAS Number:
57459-72-0
MDL number:
MFCD00131294
NACRES:
NA.77

storage temp.

2-8°C

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This Item
H5515H33932106
Heparan sulfate sodium salt from bovine kidney

Sigma-Aldrich

H7640

Heparan sulfate sodium salt from bovine kidney

Heparin sodium salt from porcine intestinal mucosa ≥150 IU/mg (dry basis)

Sigma-Aldrich

H5515

Heparin sodium salt from porcine intestinal mucosa

Heparin sodium salt from porcine intestinal mucosa Grade I-A, ≥180 USP units/mg

Sigma-Aldrich

H3393

Heparin sodium salt from porcine intestinal mucosa

Sigma-Aldrich

Sigma-Aldrich

2106

Heparin sodium salt from porcine intestinal mucosa

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Application

Heparan sulfate sodium salt from bovine kidney has been used:
  • to investigate its effect on proliferation of B cells
  • to monitor its role on eye development in E5 embryonic cells
  • to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot

Biochem/physiol Actions

Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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