Merck
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P4498

Sigma-Aldrich

Pravastatin sodium salt hydrate

≥98% (HPLC), powder

All Photos(1)
Synonym(s):
(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
Empirical Formula (Hill Notation):
C23H35O7Na · xH2O
CAS Number:
81131-70-6
Molecular Weight:
446.51 (anhydrous basis)
MDL number:
MFCD00887601
PubChem Substance ID:
329820206
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

mp

171.2-173 °C

solubility

H2O: >10 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

SMILES string

[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O

InChI

1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

InChI key

VWBQYTRBTXKKOG-IYNICTALSA-M

Gene Information

human ... HMGCR(3156)

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This Item
PHR34075244031554206
Pravastatin sodium salt hydrate ≥98% (HPLC), powder

Sigma-Aldrich

P4498

Pravastatin sodium salt hydrate

Supelco

Supelco

PHR3407

Pravastatin Sodium

Pravastatin, Sodium Salt A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

Sigma-Aldrich

524403

Pravastatin, Sodium Salt

USP

USP

1554206

Pravastatin sodium

form

powder

form

-

form

crystalline solid

form

-

color

white

color

-

color

white

color

-

solubility

H2O: >10 mg/mL

solubility

-

solubility

water: 100 mg/mL

solubility

-

originator

Bristol-Myers Squibb

originator

-

originator

-

originator

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Cerivastatin sodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0005

Cerivastatin sodium salt hydrate

vibrant-m

Y0000223

Pravastatin impurity A

Lovastatin Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

Sigma-Aldrich

438185

Lovastatin

Mevastatin An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.

Sigma-Aldrich

474700

Mevastatin

USP

USP

1554228

Pravastatin Related Compound B

Lovastatin, Sodium Salt Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

Sigma-Aldrich

438186

Lovastatin, Sodium Salt

Statins for treating stable angina: can statins improve the plaque morphology and angina?
Cheol Whan Lee et al.
Future cardiology, 9(2), 155-158 (2013-03-08)
Kevin F Erickson et al.
Journal of the American College of Cardiology, 61(12), 1250-1258 (2013-03-19)
The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase
S M Singhvi et al.
British journal of clinical pharmacology, 29(2), 239-243 (1990-02-01)
Pravastatin sodium, a competitive inhibitor of HMG-CoA reductase, is a new orally effective hypocholesterolaemic agent. In a two-way crossover study, eight healthy male subjects each received an intravenous and an oral dose of [14C]-pravastatin sodium. The oral absorption of [14C]
[Dermatomyositis].
Sylvain Glitho et al.
La Revue du praticien, 63(5), 626-626 (2013-06-26)
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Nature medicine, 19(5), 515-515 (2013-05-09)
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