Cell signaling

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Myosins are a family of ATP-dependent motor proteins. Myosin II is the major contractile protein involved in eukaryotic muscle contraction by “walking” along actin microfilaments of the sarcomere

Detect, Visualize and Quantify Single Post-Translational Modifications

Sigma-Aldrich presents a Biofiles on Detect, Visualize and Quantify Single Post-Translational Modifications

Biglycan

Biglycan is a 200-350 kDa(proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains.

Spectrin

Spectrin is the major component of the protein network, which covers the cytoplasmic surface of vertebrate, erythrocyte membranes. It is a high molecular weight heterodimer, composed of two subunits (molecular weights of approximately 230 kDa and 250 kDa)

VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

Insulin-like Growth Factors (IGF)

Transient Receptor Potential Channels

We offer many products related to transient receptor potential channels for your research needs.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Discover Bioactive Small Molecules for Lipid Signaling Research

Leukotriene Receptors

We offer many products related to leukotriene receptors for your research needs.

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Somatostatin Receptors

Somatostatin (somatotropin release-inhibiting factor, SRIF) is a cyclic peptide widely expressed throughout the CNS, endocrine tissues, and gastrointestinal tract.

GABAC Receptors

Introduction to GABAC receptors as well as modulators and other products for your research needs.

Serotonin Receptors

We offer many products related to serotonin receptors for your research needs.

Nuclear Receptors (Non-Steroids)

We offer many products related to non-steroid nuclear receptors for your research needs.

GABAA Receptors

We offer many products related to GABAA receptors for your research needs.

GABA Transporters

Sigma-Aldrich offers many products related to GABA transporters for your research needs.

Dopamine Receptors

We offer many products related to dopamine receptors for your research needs.

Dopamine, Norepinephrine and Ephinephrine Synthesis

Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Troponin

Troponin together with tropomyosin, regulate the binding of myosin to actin. Troponin is a trimeric protein composed of Troponin subunits I, C and T. Troponin C binds calcium ions, Troponin T binds to tropomyosin and troponin I binds

Mitochondrial Stress and ROS

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

Cholesterol Biosynthesis Regulation

Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.

Glutamate/GABA Synthesis & Metabolism

Glutamine's role in neurotransmitter synthesis and transport highlights its importance in neuronal function and glutamate production.

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

InsP3/Ryanodine Receptors

Ryanodine and InsP3 receptors share structural and functional similarities, forming calcium channels.

Sialic Acid

Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

Heterotrimeric G Proteins

Heterotrimeric G proteins modulate intracellular signals from 7TM receptors, impacting various cellular functions and drug targets.

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