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Cell Design Studio® Cell Engineering Services

Cell Engineering Services Designed to Help You Find Answers

Cell Design Studio® engineering provides custom, genetically modified cellular models developed using an immersive consultative approach. We partner with you, taking the labor-intensive steps of creating cell lines off your hands so you can focus on the science. With unparalleled expertise, exceptionally precise tools, and a full suite of intellectual property, we help you find answers that no one else can.

KNOCKOUT, KNOCK-IN, AND EVERYTHING IN BETWEEN

Using state-of-the-art genome editing technologies (CRISPR, ZFN, and RNAi), and innovative methods for clonal selection and isolation, we generate targeted modifications of any gene, in virtually any cell line. From a patient-derived iPS cell line with a disease SNP corrected, to a novel immunotherapy target overexpressed in a cancer cell line, to an endogenously-tagged fluorescent reporter cell line for high-content screening, to a Cas9 expression line, our experts will take any project from proposal to reality.

We have options to suit any downstream application with Cell Design Studio® Classic projects for research use, and Cell Design Studio® Ultra projects if you need traceability, enhanced documentation, and regulatory expertise for pre-clinical and clinical development or biomanufacturing.

Flow chart of cell engineering steps, and one below showing the Cell Design Studio® service goes directly from choosing a model to cells ready to use.

Immunotherapy

Our Cell Design Studio® engineers deliver high-quality, biologically relevant models including novel immunotherapy cell lines, screening tools for CAR/TCR therapies, and target cells for efficacy testing in therapeutic manufacturing.

  • CAR-T target reporters
  • Tumor antigen expression cell lines
  • Checkpoint inhibitor knockout & overexpression
  • Therapeutic antibody knockout & overexpression
  • T-cell receptor modifications
  • Engineered cells for cell/gene therapy evaluation (RUO)

PLURIPOTENT STEM AND PRIMARY CELLS

Pluripotent stem cells can be modified for disease modeling in vitro, small molecule screening, or optimizing differentiation protocols. We can edit your iPSC lines, or our available in-house iPSCs.

  • Isogenic IPS and SNP modifications
  • Reporter and lineage tagging for directed differentiation protocol development
  • Knockout/knock-in for drug discovery
  • Cas9 overexpression for CRISPR screening
  • Safe-harbor integration of dCas9-based effectors

CELL-BASED ASSAYS FOR DRUG DISCOVERY

Let our cell line engineering experts create research models using our full suite of genome editing tools and cell lines for applications like small molecule and drug screening or high-throughput screening with endogenously-tagged fluorescent reporter cell lines.

  • Cell viability/proliferation
  • Cell migration/localization
  • Apoptosis/cell death detection
  • Directed differentiation of iPS cells
  • Copy number variation (CNV) analysis

CELL DESIGN STUDIO® ULTRA ENGINEERING FOR PROCESS DEVELOPMENT AND BIOMANUFACTURING

Get the same flexibility, dedicated project management, and state-of-the-art technical capabilities offered for research and discovery projects with additional regulatory expertise for pre-clinical and clinical development, biomanufacturing, and quality control.

  • Therapeutic manufacturing
  • Potency assays
  • Batch release assays

Comparing project deliverables between a Classic and Ultra cell engineering project

Our technical and regulatory expertise is unmatched, and we are dedicated to partnering with you to move your research to clinical development and manufacturing. Every project is customized and validated so you get not just cell line, but a successful solution.


WANT TO DISCUSS A POTENTIAL PROJECT?

Speak to one of our engineering experts and find out how we can help you achieve your most ambitious research goals!



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