Hepatocyte Growth Factor (HGF)
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for a receptor encoded by the c-met proto-oncogene. c-Met expression has been observed in tumors from many sources, including stomach, lung, breast, kidney colon, liver, and melanoma, and is associated with tumor progression and metastasis.
Hepatocyte Growth Factor (HGF)
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References
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Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. 2003. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4(12):915-925. https://doi.org/10.1038/nrm1261
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Zhang Y, Vande Woude GF. 2003. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem.. 88(2):408-417. https://doi.org/10.1002/jcb.10358