C–H Functionalization Reaction Manual

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Streamline Your Chemical Synthesis

Request Your Copy of Our All-Inclusive Manual on C–H Functionalization

We’re dedicated to supporting all your explorations. Learn about common C–H functionalization reactions so you can intuitively predict where and how to apply them and further explore the field with our new guide. Get your copy below.

C–H functionalization has been called the holy grail of synthetic organic chemistry. The reliable and predictable conversion of a C–H into a C–C, C–N, C–O or C–X bond in a selective and controlled fashion represents a host of benefits in terms of step economy and waste reduction, driving the current energetic pace of research in this area.

C–H functionalization not only expands the number of sites that can be targeted in a given molecule, multiplying the opportunities for elaborating it into a more complex product, but it also allows for completely different kinds of chemical bonds to be targeted, often with high chemoselectivity.

Setting Up Synthetic Chemists for Success

  • Curated list of specific C–H functionalization reactions
  • Reaction tips straight from the reaction developers
  • Clearly illustrated synthetic value disconnections
  • Reactivity and selectivity predictions organized by reaction class
  • Examples showcase the power and selectivity of possible transformations

Method for a different set of rules

About the Authors

  • Dr. Julian G. West, California Institute of Technology
  • Dr. Daniel Morton, Emory University
  • Dr. T. Aaron Bedell, Stanford University
  • James B. C. Mack, Stanford University

The life science business of Merk KGaA, Darmstadt, Germany has long partnered with the scientists in the field to support their explorations by sharing knowledge, providing educational resources, and being a reliable supplier of cutting-edge materials. This guide was developed in collaboration with chemists from the Center for Selective C-H Functionalization, a National Science Foundation Center for Chemical Innovation


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