BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
别名:
HUCEP-13, UCHL2
物种:
Human BAP1 (8314), Mouse Bap1 (104416), Rat Bap1 (306257), Thale Cress BAP1 (825291), domestic cat BAP1 (101092671), domestic guinea pig Bap1 (100731081), Zebrafish bap1 (558885), chicken BAP1 (415944), naked mole-rat Bap1 (101703932), dog BAP1 (484737) ...展开
UniProtKB ID:
基因ID:
- Human(8314) Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
- Mouse(104416) Brca1 associated protein 1
- Rat(306257) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- Thale Cress(825291) BON association protein 1
- domestic cat(101092671) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- domestic guinea pig(100731081) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- Zebrafish(558885) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- chicken(415944) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- naked mole-rat(101703932) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- dog(484737) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- cow(100124510) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- Horse(100051934) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
- sheep(101111666) BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
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