157945

Sigma-Aldrich

(4-羧丁基)三苯基溴化膦

98%

别名:
5-(Triphenylphosphonio)pentanoic acid bromide, Carboxybutyltriphenylphosphonium bromide, NSC 147756
线性分子式:
(C6H5)3P(Br)(CH2)4COOH
CAS号:
分子量:
443.31
Beilstein/REAXYS Number:
3586477
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

200

测定

98%

reaction suitability

reaction type: C-C Bond Formation

mp

204-207 °C (lit.)

SMILES string

[Br-].OC(=O)CCCC[P+](c1ccccc1)(c2ccccc2)c3ccccc3

InChI

1S/C23H23O2P.BrH/c24-23(25)18-10-11-19-26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22;/h1-9,12-17H,10-11,18-19H2;1H

InChI key

MLOSJPZSZWUDSK-UHFFFAOYSA-N

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应用

  • 用作促凋亡肽递送至肿瘤细胞线粒体的平台

制备用反应物:
  • 通过关环置换和双键迁移关环置换反应得到的环骨架
  • 甲基烯基喹诺酮类抗分枝杆菌药物
  • 通过金催化 Meyer-Schuster 重排的前列腺素及其药物类似物
  • 二苯基甲基哌嗪作为 N 型钙通道阻滞剂作为潜在的治疗药物
  • 具有抗肿瘤活性的叶酸受体特异性甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFTase) 抑制剂
  • 通过 Wittig 反应测定具有抗利什曼病活性的环烷基烷醇

包装

50, 250 g in poly bottle

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书

原产地证书 (CofO)

Sabah Haq et al.
OncoTargets and therapy, 10, 2427-2447 (2017-05-13)
Prostaspheres-based three dimensional (3D) culture models have provided insight into prostate cancer (PCa) biology, highlighting the importance of cell-cell interactions and the extracellular matrix (EMC) in the tumor microenvironment. Although these 3D classical spheroid platforms provide a significant advance over...
O O Koloskova et al.
Colloids and surfaces. B, Biointerfaces, 167, 328-336 (2018-04-24)
Development of efficient biodegradable, environmentally responsive, biocompatible and non-toxic delivery system is needed for efficient gene delivery. As well known, properties of the vehicle are determined by the structure of carrier components. The aim of the current study was to...
Da Huo et al.
Nature communications, 10(1), 3051-3051 (2019-07-13)
Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner. Nucleus-targeting W18O49 nanoparticles (WONPs) are conjugated to mitochondria-selective mesoporous silica...
Gantumur Battogtokh et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 733-743 (2016-11-07)
The objective of this study was to develop a mitochondria-targeted photosensitizer (PS) for photodynamic therapy (PDT). Herein, a porphyrin-derivative photosensitizer, pheophorbide-a (PheoA), was conjugated to carboxybutyltriphenylphosphonium (TPP) via a carbodiimide linkage to enhance mitochondrial targeting and TPP-PheoA conjugate was further...
Raquel Palao-Suay et al.
Journal of materials science. Materials in medicine, 28(10), 152-152 (2017-09-02)
Active targeting not only of a specific cell but also a specific organelle maximizes the therapeutic activity minimizing adverse side effects in healthy tissues. The present work describes the synthesis, characterization, and in vitro biological activity of active targeting nanoparticles (NP)...

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