Merck

183938

Sigma-Aldrich

2,3,5,6-四甲基吡嗪

98%

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别名:
2,3,5,6-Tetramethylpyrazine, Ligustrazin, Ligustrazine, Tetrapyrazine
经验公式(希尔记法):
C8H12N2
CAS号:
分子量:
136.19
Beilstein:
113100
EC 号:
MDL编号:
eCl@ss:
39161809
PubChem化学物质编号:
NACRES:
NA.22

检测方案

98%

形式

solid

bp

190 °C (lit.)

mp

77-80 °C (lit.)

SMILES string

Cc1nc(C)c(C)nc1C

InChI

1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

InChI key

FINHMKGKINIASC-UHFFFAOYSA-N

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此商品
W323705W323713W324418
vibrant-m

183938

2,3,5,6-四甲基吡嗪

vibrant-m

W323705

2,3,5,6-四甲基吡嗪

vibrant-m

W323713

2,3,5,6-四甲基吡嗪

vibrant-m

W324418

2,3,5-三甲基吡嗪

Quality Level

100

Quality Level

400

Quality Level

400

Quality Level

400

form

solid

form

-

form

-

form

-

bp

190 °C (lit.)

bp

190 °C (lit.)

bp

190 °C (lit.)

bp

171-172 °C (lit.)

mp

77-80 °C (lit.)

mp

77-80 °C (lit.)

mp

77-80 °C (lit.)

mp

-

一般描述

2,3,5,6-四甲基吡嗪是从麻黄中分离得到的。它可用于治疗多种疾病,如哮喘、心力衰竭、鼻炎和尿失禁。它是烟草的一种香味成分。其与 4-羟基苯甲酸形成共晶,表现出超分子合成子多晶型

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Gyoseon Goya M Yeom et al.
International immunopharmacology, 18(2), 262-269 (2013-12-18)
2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and
B R Sreekanth et al.
Chemical communications (Cambridge, England), (23)(23), 2375-2377 (2007-09-12)
Co-crystals of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine (2 : 1) exhibit the first supramolecular synthon polymorphism in a co-crystal; metastable anti-hierarchic polymorph I converts to stable hierarchic form II.
Christopher R E Coggins et al.
Inhalation toxicology, 23 Suppl 1, 84-89 (2011-04-05)
Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. A battery of tests was used to compare the toxicity of mainstream smoke from
Huda M AlKreathy et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(8), 916-926 (2020-08-15)
Available antiulcer medications reveal partial efficacy and numerous adverse reactions. Tetramethylpyrazine (TMP) was known for its potential antioxidant, anti-inflammatory and angiogenic properties. The aim of current study was to investigate the potential gastroprotective effect of TMP against indomethacin-induced gastric ulcer
Hongfei Chen et al.
European journal of medicinal chemistry, 46(11), 5609-5615 (2011-10-14)
A series of novel ligustrazinyloxy-cinnamic acid derivatives were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro, and also assayed for their protective effect against hydrogen peroxide (H(2)O(2))-induced oxidative damage on ECV-304 cells.

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