Merck

202495

Sigma-Aldrich

聚乙二醇甲基醚

average Mn 750

别名:
mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚
线性分子式:
CH3(OCH2CH2)nOH
CAS号:
MDL编号:
PubChem化学物质编号:

蒸汽密度

>1 (vs air)

质量水平

蒸汽压

0.05 mmHg ( 20 °C)

形式

paste
solid

分子量

average Mn 750

折射率

n20/D 1.459

粘度

10.5 cSt(210 °F)(lit.)

转变温度

Tm 30 °C

密度

1.094 g/mL at 25 °C

Ω端

hydroxyl

α端

methoxy

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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8132320248771578
Poly(ethylene glycol) methyl ether average Mn 750

Sigma-Aldrich

202495

聚乙二醇甲基醚

Poly(ethylene glycol) methyl ether average Mn 5,000

Sigma-Aldrich

81323

聚乙二醇甲基醚

Poly(ethylene glycol) methyl ether average Mn 550

Sigma-Aldrich

202487

聚乙二醇甲基醚

Poly(ethylene glycol) methyl ether BioUltra, 500

Sigma-Aldrich

71578

聚乙二醇甲基醚

mol wt

average Mn 750

mol wt

average Mn 5,000

mol wt

average Mn 550

mol wt

470-530

transition temp

Tm 30 °C

transition temp

-

transition temp

Tm 20 °C

transition temp

-

density

1.094 g/mL at 25 °C

density

-

density

1.089 g/mL at 25 °C

density

-

Ω-end

hydroxyl

Ω-end

hydroxyl

Ω-end

hydroxyl

Ω-end

-

α-end

methoxy

α-end

methoxy

α-end

methoxy

α-end

-

应用

聚(乙二醇)甲基醚可用作:
  • 一种链转移剂,以通过金属开环寡聚反应合成两亲性嵌段共聚物。
  • 作为一种前体,用于制备视甲酸-聚乙二醇纳米组装体,以作为一种高效的药物给药系统
  • 制备与聚乳酸结合的双嵌段共聚物,并将其应用于组织工程和给药领域

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(F)

359.6 °F - closed cup

闪点(C)

182 °C - closed cup

个人防护装备

Eyeshields, Gloves


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Yi Wei et al.
Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
Junhwa Shin et al.
Molecular pharmaceutics, 9(11), 3266-3276 (2012-10-04)
A family of 3-methoxypoly(ethylene glycol)-vinyl ether-1,2-dioleylglycerol (mPEG-VE-DOG) lipopolymer conjugates, designed on the basis of DFT calculations to possess a wide range of proton affinities, was synthesized and tested for their hydrolysis kinetics in neutral and acidic buffers. Extruded ∼100 nm
Yunki Lee et al.
Colloids and surfaces. B, Biointerfaces, 102, 585-589 (2012-10-30)
The control of biological interactions that occur at material-cell/blood interfaces is of great importance to help maximize in vitro and in vivo performance of biomedical devices. PEGylation has been extensively used as an effective surface modification tool that can alter
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in

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