Merck
All Photos(1)

23261

Sigma-Aldrich

氯甲酸三氯甲酯

≥97.0% (GC)

Synonym(s):
TCF, 双光气, 氯代甲酸三氯甲酯
Linear Formula:
ClCOOCCl3
CAS Number:
Molecular Weight:
197.83
Beilstein:
970225
EC 号:
MDL编号:
PubChem化学物质编号:

质量水平

测定

≥97.0% (GC)

折射率

n20/D 1.458

bp

20 °C/10 mmHg (lit.)

密度

1.639 g/mL at 20 °C

储存温度

2-8°C

SMILES string

ClC(=O)OC(Cl)(Cl)Cl

InChI

1S/C2Cl4O2/c3-1(7)8-2(4,5)6

InChI key

HCUYBXPSSCRKRF-UHFFFAOYSA-N

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Trichloromethyl chloroformate ≥97.0% (GC)

Sigma-Aldrich

23261

氯甲酸三氯甲酯

Chloromethyl chloroformate ≥98.0% (GC)

Sigma-Aldrich

23181

氯甲酸氯甲酯

assay

≥97.0% (GC)

assay

98%

assay

≥98.0% (GC)

assay

97%

refractive index

n20/D 1.458

refractive index

n20/D 1.471 (lit.)

refractive index

n20/D 1.428

refractive index

n20/D 1.446 (lit.)

bp

20 °C/10 mmHg (lit.)

bp

171-172 °C (lit.)

bp

107-108 °C (lit.)

bp

155-156 °C (lit.)

density

1.639 g/mL at 20 °C

density

1.539 g/mL at 25 °C (lit.)

density

1.450 g/mL at 20 °C

density

1.385 g/mL at 25 °C (lit.)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

应用

制备反应物:
  • 使用单膦金(i)催化剂的环状氨基甲酰亚胺酯
  • N-烯基和环烷基氨基甲酸酯作为双重作用的组胺 H3 和 H4 受体配体
  • 前列腺特异性膜抗原靶向抗癌前药
  • 潜在的西尼罗河病毒蛋白酶抑制剂
  • 抗体 - 药物偶联物(ADC)
  • 红霉素 A 衍生物
氯甲酸三氯甲酯(TCF)是光气的有效替代物。它可以与胺、氨基酸和氨基醇反应,得到相应的异氰酸酯、异氰酸根合酰氯和异氰酸根合氯代甲酸酯。
TCF 也可用于:
  • 合成 N-羧基 α-氨基酸酐。
  • 作为酰化剂,由 α-氨基醇合成恶唑烷酮。
  • 作为脱水剂,在三乙胺存在下合成芳香族二异氰化物。

其他说明

光气的易处理替代品;可通过原位炭催化分解成光气,并可与氨基酸反应生成 N-羧酸酐

象形图

CorrosionSkull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Skin Corr. 1B

储存分类代码

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificate of Analysis

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Certificate of Origin

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