Merck
所有图片(1)

467804

Sigma-Aldrich

羟胺 溶液

50 wt. % in H2O, 99.999%

别名:
HDA
线性分子式:
NH2OH
CAS号:
分子量:
33.03
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

测定

99.999%

浓度

50 wt. % in H2O

bp

107 °C

密度

1.078 g/mL at 25 °C

SMILES string

NO

InChI

1S/H3NO/c1-2/h2H,1H2

InChI key

AVXURJPOCDRRFD-UHFFFAOYSA-N

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应用

羟胺溶液(NH2OH)可作为反应物用于制备:
  • 来自醛类的伯酰胺,通过芳烃钌(II)络合物催化。
  • 羟基氨基胍和生物研究用氧氟沙星的甲酰胺衍生物。
  • 用于抗体固定化的Fe3O4/Au (GoldMag)纳米颗粒。

作为制备下列化合物的反应物:
  • 心血管药物 Nω-羟基-L-精氨酸(NOHA,一氧化氮前体)的前药
  • 羟基氨基胍,作为抗癌药
  • 非甾体2,3-二氢喹啉糖皮质激素受体激动剂,具有降低的磷酸烯醇丙酮酸羧基激酶(PEPCK)转录激活活性
  • 氧氟沙星的羧酰胺衍生物,具有改善的抗菌特性
  • 基于香豆素类似物的TNF-α转化酶(TACE)抑制剂
  • HIV整合酶抑制剂

包装

10, 50 mL in poly bottle

警示用语:

Danger

危险分类

4 - Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3

靶器官

Blood, Respiratory system

储存分类代码

3 - Flammable liquids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析证书

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原产地证书 (CofO)

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N-Hydroxy-N′-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation
Basu A, et al.
Bioorganic & Medicinal Chemistry Letters, 21(11), 3324-3328 (2011)
Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
Arayne MS, et al.
Archives of Pharmacal Research, 33(12), 1901-1909 (2010)
The synthesis of GoldMag nano-particles and their application for antibody immobilization
Cui Y, et al.
Biomedical Microdevices, 7(2), 153-156 (2005)
Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water
Garcia-Alvarez R, et al.
Royal Society of Chemistry Advances, 3(17), 5889-5894 (2013)
Rika Goda et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(5), 828-835 (2006-03-02)
Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide), a nonsteroidal antiandrogen, is used in the treatment of prostate cancer but is occasionally associated with hepatic dysfunction. In the present study, the metabolism of flutamide including the formation of the possible reactive toxic metabolites was investigated using

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