488712

Sigma-Aldrich

(三氟甲基)三甲基硅烷

99%

别名:
(Trifluoromethyl)trimethylsilane, Ruppert 试剂, TFMTMS
线性分子式:
(CH3)3SiCF3
CAS号:
分子量:
142.19
Beilstein/REAXYS Number:
4241868
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

200

测定

99%

reaction suitability

reaction type: C-C Bond Formation

bp

54-55 °C (lit.)

密度

0.962 g/mL at 20 °C (lit.)

储存温度

2-8°C

SMILES string

C[Si](C)(C)C(F)(F)F

InChI

1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3

InChI key

MWKJTNBSKNUMFN-UHFFFAOYSA-N

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应用

三甲基(三氟甲基)硅烷可以在以下过程中用作三氟甲基化剂:
  • N-(-丁基亚磺酰基)-亚胺转化为三氟甲基化胺
  • 反式-烯酮转化为反式-α-三氟甲基甲硅烷基醚
  • 偶氮甲亚胺的三氟甲基化
  • H-膦酸酯转化为CF3-膦酸酯
  • 三氟甲基通过亲核加成转化成醛和酮。

包装

5, 25 mL in glass bottle

象形图

Flame

警示用语:

Danger

危险声明

hazcat

Flam. Liq. 2 - Water-react. 2

storage_class_code

4.3 - Hazardous materials, which set free flammable gases upon contact with water

WGK Germany

WGK 3

闪点(F)

1.4 °F - closed cup

闪点(C)

-17 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves

分析证书

原产地证书 (CofO)

Peter T Kaplan et al.
Beilstein journal of organic chemistry, 13, 2297-2303 (2017-11-29)
A number of copper reagents were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any bottlenecks, and provide more insight into the...
Stereoselective Nucleophilic Trifluoromethylation of N?(tert?Butylsulfinyl) imines by Using Trimethyl (trifluoromethyl) silane.
Prakash G K, et al.
Angewandte Chemie (International Edition in English), 113(3), 609-610 (2001)
Catalytic enantioselective trifluoromethylation of azomethine imines with trimethyl (trifluoromethyl) silane
Kawai H, et al.
Angewandte Chemie (International Edition in English), 121(34), 6442-6445 (2009)
CsF-catalyzed nucleophilic trifluoromethylation of trans-enones with trimethyl (trifluoromethyl) silane: A facile synthesis of trans-?-trifluoromethyl allylic alcohols.
Singh R P, et al.
Organic Letters, 1(7), 1047-1049 (1999)
Copper-catalyzed aerobic oxidative trifluoromethylation of H-phosphonates using trimethyl (trifluoromethyl) silane
Chu L, et al.
Synthesis, 44(10), 1521-1525 (2012)

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