Merck

595314

Sigma-Aldrich

1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑

95%

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别名:
1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑, 1-甲基-4-吡唑硼酸频哪醇酯
经验公式(希尔记法):
C10H17BN2O2
分子量:
208.07
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

95%

形式

solid

mp

59-64 °C (lit.)

SMILES字符串

Cn1cc(cn1)B2OC(C)(C)C(C)(C)O2

InChI

1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3

InChI key

UCNGGGYMLHAMJG-UHFFFAOYSA-N

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1 of 4

此商品
698628525057704776
vibrant-m

698628

1-甲基-1H-吡唑-5-硼酸频哪醇酯

vibrant-m

525057

4-吡唑硼酸频哪醇酯

form

solid

form

powder

form

solid

form

powder

mp

59-64 °C (lit.)

mp

67-71 °C

mp

142-146 °C (lit.)

mp

56-58 °C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

应用

稳定的硼酸替代品,用于Suzuki-Miyaura钯催化交叉偶联
试剂用于
  • Suzuki-Miyaura交叉偶联反应
  • 酯交换反应

用于制备
  • 氨基噻唑类(γ)-分泌酶调节剂
  • 氨基吡啶-吲哚甲酰胺,作为骨髓增生性疾病治疗的潜在 JAK2 抑制剂
  • 吡啶衍生物作为 TGF-β1 和激活素 A 信号传导抑制剂
  • MK-2461 类似物作为 c-Met 激酶抑制剂治疗癌症

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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其他客户在看

Brijesh Bhayana et al.
Organic letters, 11(17), 3954-3957 (2009-08-12)
A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed
Direct conversion of pinacol arylboronic esters to aryl triolborates
Li, G.-Q.; et al.
Chemistry Letters (Jpn), 40, 702-704 (2011)
Suzuki-Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines
Asano, S.; Kamioka, S.; Isobe, Y.
Tetrahedron, 68, 272-279 (2012)
Guopin Xu et al.
Organic letters, 7(21), 4605-4608 (2005-10-08)
[reaction: see text] The synthesis of a series of NHC building blocks that can then be incorporated into more complicated structures by palladium catalysis is reported. This approach is used for the synthesis of three amino acids containing NHC side
Jason D Katz et al.
Journal of medicinal chemistry, 54(12), 4092-4108 (2011-05-26)
c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an attractive cancer drug target, triggering a number of approaches to

商品

The Suzuki-Miyaura cross-coupling reaction is an important and extensively used reaction in organic chemistry with applications in polymer science and in the fine chemicals and pharmaceutical industries.

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