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Merck

732613

Sigma-Aldrich

聚乙二醇甲基醚

average MN 20,000, methoxy, hydroxyl

别名:

mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚

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About This Item

线性分子式:
CH3(OCH2CH2)nOH
CAS号:
MDL號碼:
分類程式碼代碼:
12162002
NACRES:
NA.23

product name

聚乙二醇甲基醚, average Mn 20,000

蒸汽密度

>1 (vs air)

品質等級

蒸汽壓力

0.05 mmHg ( 20 °C)

形狀

powder or crystals

分子量

average Mn 20,000

mp

64-69 °C

Mw/Mn

≤1.2

Ω-end

hydroxyl

α-end

methoxy

儲存溫度

−20°C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI 密鑰

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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應用

  • Deoxycholic acid-grafted PEGylated chitosan micelles for the delivery of mitomycin C.:开发脱氧胆酸接枝的PEG化壳聚糖胶束用于有效递送丝裂霉素C,说明PEG化物质在药物制剂和药物传输系统中的应用前景(Zhang et al., 2015)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

359.6 °F

閃點(°C)

182 °C


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Jiani Zheng et al.
Langmuir : the ACS journal of surfaces and colloids, 28(37), 13261-13273 (2012-08-28)
Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness
Lei Liu et al.
International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
Junhwa Shin et al.
Molecular pharmaceutics, 9(11), 3266-3276 (2012-10-04)
A family of 3-methoxypoly(ethylene glycol)-vinyl ether-1,2-dioleylglycerol (mPEG-VE-DOG) lipopolymer conjugates, designed on the basis of DFT calculations to possess a wide range of proton affinities, was synthesized and tested for their hydrolysis kinetics in neutral and acidic buffers. Extruded ∼100 nm
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in

商品

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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